ID   TO4AB_XENLA             Reviewed;         418 AA.
AC   Q3KQ18;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Torsin-4A-B;
DE   AltName: Full=Torsin family 4 member A-B;
GN   Name=tor4a-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC106423; AAI06424.1; -; mRNA.
DR   RefSeq; NP_001089731.1; NM_001096262.1.
DR   AlphaFoldDB; Q3KQ18; -.
DR   SMR; Q3KQ18; -.
DR   GeneID; 734794; -.
DR   KEGG; xla:734794; -.
DR   CTD; 734794; -.
DR   Xenbase; XB-GENE-17333059; tor4a.L.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 734794; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010448; Torsin.
DR   InterPro; IPR030551; Torsin-4A.
DR   PANTHER; PTHR10760; PTHR10760; 1.
DR   PANTHER; PTHR10760:SF1; PTHR10760:SF1; 1.
DR   Pfam; PF06309; Torsin; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..418
FT                   /note="Torsin-4A-B"
FT                   /id="PRO_0000287493"
FT   TRANSMEM        128..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         200..207
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   418 AA;  48085 MW;  2EDEA63CB81330FE CRC64;
     MEESESQAPV PPHGISLVSS PVRAVIRIRR KIRTMKKSRL QVDLTGERSL DSAKASLRRQ
     ISMDRASLFK SSTYEKQQYF NFDTPTLEKL ALTSQIRKRN RNKSRHVLYP GNVRKCLPVE
     QKSKAKRCLL LFVGIVCFQI FNAIENLDDN LQKYDLDGLE KTLQREVFGQ TRAIEKLMDH
     LKDYLATHYH NKPLVLSFNG PSGVGKSHTG RLLAKHFRSV VDNDFVLQYY TNHNCPNESD
     VIQCQAEVSA MISQMISRAE IEEKIPVFLF DEVEAMPVAL LDVLHSYFQL NQSNEYLNVV
     YILISNIGGH EITKFVLQNV SNDFFNLPQE LHQIVLSSLR KHHSLWDVAE IVPFTLLEKR
     HILDCFLDEL LREGFYPDHS NIESLAGQLR YYIKGNKEFS ISGCKQVVAK VNLLQPYT