ID   TO6BL_YEAS6             Reviewed;         264 AA.
AC   B5VNM2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Meiotic recombination protein REC102;
GN   Name=REC102; ORFNames=AWRI1631_123570;
OS   Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=545124;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AWRI1631;
RX   PubMed=18778279; DOI=10.1111/j.1567-1364.2008.00434.x;
RA   Borneman A.R., Forgan A.H., Pretorius I.S., Chambers P.J.;
RT   "Comparative genome analysis of a Saccharomyces cerevisiae wine strain.";
RL   FEMS Yeast Res. 8:1185-1195(2008).
CC   -!- FUNCTION: Required for formation of the SPO11-mediated double-strand
CC       breaks (DSBs) that initiate meiotic recombination. May mediate the
CC       interaction between SPO11 subunits during meiosis. Also needed for
CC       homolog chromosome pairing, synaptonemal complex formation, and for the
CC       proper timing of the first meiotic division. Not required for mitosis
CC       and mitotic DNA repair mechanisms. {ECO:0000250|UniProtKB:Q02721}.
CC   -!- SUBUNIT: Interacts with REC104; seems to form a functional unit with
CC       REC104. REC102-REC104 interacts with SKI8-SPO11 and this interaction is
CC       required for proper subcellular location of the proteins during the
CC       initiation of recombination. Interacts with MEI4, REC114 and SPO11.
CC       {ECO:0000250|UniProtKB:Q02721}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02721}.
CC       Note=Associates with chromatin during prophase. Recruitment to
CC       chromatin depends on REC104, SPO11 and SKI8.
CC       {ECO:0000250|UniProtKB:Q02721}.
CC   -!- MISCELLANEOUS: Despite weak sequence similarities, may correspond to
CC       the subunit B of a SPO11-containing topoisomerase 6 complex
CC       specifically required for meiotic recombination. Retains some of the
CC       structural features of the ancestral archaeal Top6B subunit (AC
CC       O05207). {ECO:0000250|UniProtKB:Q02721}.
CC   -!- SIMILARITY: Belongs to the TOP6B-like family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDZ70474.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; ABSV01001671; EDZ70474.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; B5VNM2; -.
DR   PRIDE; B5VNM2; -.
DR   Proteomes; UP000008988; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Meiosis; Nucleus.
FT   CHAIN           1..264
FT                   /note="Meiotic recombination protein REC102"
FT                   /id="PRO_0000377625"
FT   REGION          200..221
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   264 AA;  30256 MW;  E306B2197CCEF559 CRC64;
     MARDITFLTV FLESCGAVNN DEAGKLLSAW TSTVRIEGPE PTDSNSLYIP LLPPGMLKIK
     LNFKMNDRLV TEEQELFTKL REIVGSSIRF WEEQLFYQVQ DVSTIENHVI LSLKCTILTD
     AQISTFISKP RELHTHAKGY PEIYYLSELS TTVNFFSKEG NYVEISHVIP HFNEYFSSLI
     VSQLEFEYPM VFSMISRLRL KWQQSSLAPI SYALTSNSVL LPIMLNMIAQ DKSSTTAYQI
     LCRRRGPPIQ NFQIFSIPAV TYNK