ID   TOA1_ENCCU              Reviewed;         157 AA.
AC   Q8SW23;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Transcription initiation factor IIA large subunit;
DE            Short=TFIIA large subunit;
GN   Name=TOA1; OrderedLocusNames=ECU03_1070;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL
RP   STAGE, AND SUBCELLULAR LOCATION.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC       polymerase II and plays an important role in transcriptional
CC       activation. {ECO:0000250}.
CC   -!- SUBUNIT: TFIIA is a heterodimer of the large subunit and the small
CC       subunit gamma. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the TFIIA subunit 1 family. {ECO:0000305}.
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DR   EMBL; AL590443; CAD26251.1; -; Genomic_DNA.
DR   RefSeq; NP_597616.1; NM_001040980.1.
DR   AlphaFoldDB; Q8SW23; -.
DR   SMR; Q8SW23; -.
DR   STRING; 284813.Q8SW23; -.
DR   GeneID; 858778; -.
DR   KEGG; ecu:ECU03_1070; -.
DR   VEuPathDB; MicrosporidiaDB:ECU03_1070; -.
DR   HOGENOM; CLU_030027_2_1_1; -.
DR   InParanoid; Q8SW23; -.
DR   OMA; TELHATW; -.
DR   OrthoDB; 1443035at2759; -.
DR   Proteomes; UP000000819; Chromosome III.
DR   GO; GO:0005672; C:transcription factor TFIIA complex; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR   Gene3D; 2.30.18.10; -; 1.
DR   InterPro; IPR004855; TFIIA_asu/bsu.
DR   InterPro; IPR009088; TFIIA_b-brl.
DR   PANTHER; PTHR12694; PTHR12694; 1.
DR   Pfam; PF03153; TFIIA; 1.
DR   SUPFAM; SSF50784; SSF50784; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..157
FT                   /note="Transcription initiation factor IIA large subunit"
FT                   /id="PRO_0000383336"
SQ   SEQUENCE   157 AA;  17817 MW;  58FA172A728FC3C6 CRC64;
     MLKIYEDIIN EVISRLEQVE DEVSIGKSAI HELRNEWRER LIEYTQSEWD GERMRRRDGE
     QGYHGYERLS EGPAHAFGGK PTTAKDPGMF EDYGSSDVSS GDSEIIGTKG STGNCMVCLY
     VKVNMSKGKW KCTFKQGFIS IGNIDFVFNS AQGELEW