ID   TOACP_TITOB             Reviewed;          65 AA.
AC   A0A1D3IY23;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2016, sequence version 1.
DT   03-AUG-2022, entry version 6.
DE   RecName: Full=Peptide ToAcP {ECO:0000303|PubMed:27917162};
DE   Flags: Precursor;
OS   Tityus obscurus (Amazonian scorpion) (Tityus cambridgei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=1221240;
RN   [1] {ECO:0000312|EMBL:SBQ16532.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 35-58, AND PROBABLE AMIDATION AT
RP   LYS-58.
RC   TISSUE=Venom gland;
RX   PubMed=27917162; DOI=10.3389/fmicb.2016.01844;
RA   Guilhelmelli F., Vilela N., Smidt K.S., de Oliveira M.A.,
RA   da Cunha Morales Alvares A., Rigonatto M.C., da Silva Costa P.H.,
RA   Tavares A.H., de Freitas S.M., Nicola A.M., Franco O.L., Derengowski L.D.,
RA   Schwartz E.F., Mortari M.R., Bocca A.L., Albuquerque P., Silva-Pereira I.;
RT   "Activity of scorpion venom-derived antifungal peptides against planktonic
RT   cells of Candida spp. and Cryptococcus neoformans and Candida albicans
RT   biofilms.";
RL   Front. Microbiol. 7:1844-1844(2016).
CC   -!- FUNCTION: Helical wheel projections predict no hydrophobic face,
CC       suggesting a non-amphipathic peptide (Probable). Does not show
CC       antifungal activity (PubMed:27917162). {ECO:0000269|PubMed:27917162,
CC       ECO:0000305|PubMed:27917162}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:27917162}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:27917162}.
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DR   EMBL; LT576031; SBQ16532.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Amidation; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..34
FT                   /evidence="ECO:0000305|PubMed:27917162"
FT                   /id="PRO_0000454904"
FT   PEPTIDE         35..58
FT                   /note="Peptide ToAcP"
FT                   /evidence="ECO:0000305|PubMed:27917162"
FT                   /id="PRO_5008915588"
FT   PROPEP          59..65
FT                   /evidence="ECO:0000305|PubMed:27917162"
FT                   /id="PRO_0000454905"
FT   MOD_RES         58
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000305|PubMed:27917162"
SQ   SEQUENCE   65 AA;  7368 MW;  97CDA065A71082A0 CRC64;
     MKMKMIVVIS ILLIVFSLSS KAMSLEDEQE SVQREEDDLL GFSEEDLKAI KEHRAKNAGR
     FDPAV