ID   TOB2_MOUSE              Reviewed;         345 AA.
AC   Q9JM55;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Protein Tob2;
DE   AltName: Full=Transducer of erbB-2 2;
GN   Name=Tob2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10940559; DOI=10.1016/s0378-1119(00)00270-5;
RA   Ajima R., Ikematsu N., Ohsugi M., Yoshida Y., Yamamoto T.;
RT   "Cloning and characterization of the mouse tob2 gene.";
RL   Gene 253:215-220(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Anti-proliferative protein inhibits cell cycle progression
CC       from the G0/G1 to S phases. {ECO:0000250}.
CC   -!- SUBUNIT: Associates with CAF1. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the BTG family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB041225; BAA94606.1; -; Genomic_DNA.
DR   EMBL; BC011163; AAH11163.1; -; mRNA.
DR   CCDS; CCDS27673.1; -.
DR   RefSeq; NP_065253.1; NM_020507.3.
DR   AlphaFoldDB; Q9JM55; -.
DR   SMR; Q9JM55; -.
DR   BioGRID; 208229; 2.
DR   IntAct; Q9JM55; 1.
DR   MINT; Q9JM55; -.
DR   STRING; 10090.ENSMUSP00000061390; -.
DR   iPTMnet; Q9JM55; -.
DR   PhosphoSitePlus; Q9JM55; -.
DR   EPD; Q9JM55; -.
DR   MaxQB; Q9JM55; -.
DR   PaxDb; Q9JM55; -.
DR   PRIDE; Q9JM55; -.
DR   ProteomicsDB; 260647; -.
DR   Antibodypedia; 26928; 157 antibodies from 26 providers.
DR   DNASU; 57259; -.
DR   Ensembl; ENSMUST00000050467; ENSMUSP00000061390; ENSMUSG00000048546.
DR   GeneID; 57259; -.
DR   KEGG; mmu:57259; -.
DR   UCSC; uc007wxm.1; mouse.
DR   CTD; 10766; -.
DR   MGI; MGI:1888525; Tob2.
DR   VEuPathDB; HostDB:ENSMUSG00000048546; -.
DR   eggNOG; KOG4006; Eukaryota.
DR   GeneTree; ENSGT00940000154208; -.
DR   HOGENOM; CLU_034687_0_0_1; -.
DR   InParanoid; Q9JM55; -.
DR   OMA; TQPMQPH; -.
DR   OrthoDB; 1439942at2759; -.
DR   PhylomeDB; Q9JM55; -.
DR   TreeFam; TF105274; -.
DR   BioGRID-ORCS; 57259; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Tob2; mouse.
DR   PRO; PR:Q9JM55; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q9JM55; protein.
DR   Bgee; ENSMUSG00000048546; Expressed in ascending aorta and 246 other tissues.
DR   ExpressionAtlas; Q9JM55; baseline and differential.
DR   Genevisible; Q9JM55; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042809; F:nuclear vitamin D receptor binding; IPI:MGI.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0045671; P:negative regulation of osteoclast differentiation; IMP:MGI.
DR   GO; GO:0030316; P:osteoclast differentiation; IMP:MGI.
DR   GO; GO:0045778; P:positive regulation of ossification; IMP:MGI.
DR   GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR   Gene3D; 3.90.640.90; -; 1.
DR   InterPro; IPR002087; Anti_prolifrtn.
DR   InterPro; IPR009818; Ataxin-2_C.
DR   InterPro; IPR036054; BTG-like_sf.
DR   InterPro; IPR015676; Tob1/2.
DR   InterPro; IPR015678; Tob2.
DR   PANTHER; PTHR17537; PTHR17537; 1.
DR   PANTHER; PTHR17537:SF3; PTHR17537:SF3; 1.
DR   Pfam; PF07742; BTG; 1.
DR   Pfam; PF07145; PAM2; 2.
DR   PRINTS; PR00310; ANTIPRLFBTG1.
DR   SMART; SM00099; btg1; 1.
DR   SUPFAM; SSF160696; SSF160696; 1.
DR   PROSITE; PS00960; BTG_1; 1.
DR   PROSITE; PS01203; BTG_2; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..345
FT                   /note="Protein Tob2"
FT                   /id="PRO_0000143816"
FT   REGION          144..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         255
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q14106"
SQ   SEQUENCE   345 AA;  36798 MW;  6DC28348E68AC976 CRC64;
     MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLRKKY EGHWYPEKPL KGSGFRCVHI
     GEVVDPVVEL AAKRSGLAVE DVRANVPEEL SVWIDPFEVS YQIGEKGVVK VLYLGDSEAS
     GTPELDKEIK SSFNPDAQVF VPIGSQDSSL SSSPSPSFGQ SPSPTFIPRS AQPITFTTAS
     FAATKFGSTK MKKGGGASGG VSVGGSGAGG QQPPPQQPRM ARSPTKNLLK HKSLSLSMHS
     LNLIPANPAP QSQLSPNAKE FVYNGGGSPS LFFDGVEGPS TSTTAPFGSG GASTCNSSSF
     DVSQVFGGGA NSLFLEKSPF VEGLSYNLNT MQYPNQPFQP VVLAN