TOCC_MAIZE
ID TOCC_MAIZE Reviewed; 474 AA.
AC Q94FY8; C0HHY8;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-DEC-2020, sequence version 2.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Tocopherol cyclase, chloroplastic {ECO:0000303|PubMed:12913173};
DE EC=5.5.1.24 {ECO:0000269|PubMed:12913173};
DE AltName: Full=Sucrose export defective 1 {ECO:0000303|PubMed:11340186};
DE Flags: Precursor;
GN Name=SXD1 {ECO:0000303|PubMed:11340186};
GN ORFNames=ZEAMMB73_Zm00001d015985 {ECO:0000312|EMBL:AQK69856.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11340186; DOI=10.2307/3871368;
RA Provencher L.M., Miao L., Sinha N., Lucas W.J.;
RT "Sucrose export defective 1 encodes a novel protein implicated in
RT chloroplast-to-nucleus signaling.";
RL Plant Cell 13:1127-1141(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. B73;
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [4]
RP FUNCTION, AND CATALYTIC ACTIVITY.
RX PubMed=12913173; DOI=10.1104/pp.103.024257;
RA Sattler S.E., Cahoon E.B., Coughlan S.J., DellaPenna D.;
RT "Characterization of tocopherol cyclases from higher plants and
RT cyanobacteria. Evolutionary implications for tocopherol synthesis and
RT function.";
RL Plant Physiol. 132:2184-2195(2003).
CC -!- FUNCTION: Involved in the synthesis of tocopherols (vitamin E), which
CC presumably protect photosynthetic complexes from oxidative stress
CC (Probable). Catalyzes the conversion of 2,3-dimethyl-5-phytyl-1,4-
CC hydroquinone (DMPQ) to gamma-tocopherol (PubMed:12913173).
CC {ECO:0000269|PubMed:12913173, ECO:0000305|PubMed:12913173}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol;
CC Xref=Rhea:RHEA:37983, ChEBI:CHEBI:18185, ChEBI:CHEBI:75921;
CC EC=5.5.1.24; Evidence={ECO:0000269|PubMed:12913173};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:37985;
CC Evidence={ECO:0000269|PubMed:12913173};
CC -!- PATHWAY: Cofactor biosynthesis; tocopherol biosynthesis. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:11340186}.
CC -!- TISSUE SPECIFICITY: Present in all green tissues, both in bundle sheath
CC and in mesophyll cells. {ECO:0000269|PubMed:11340186}.
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DR EMBL; AF302187; AAK60502.1; -; mRNA.
DR EMBL; CM000781; AQK69856.1; -; Genomic_DNA.
DR EMBL; BT061944; ACN26641.1; -; mRNA.
DR RefSeq; NP_001105015.1; NM_001111545.1.
DR AlphaFoldDB; Q94FY8; -.
DR STRING; 4577.GRMZM2G009785_P01; -.
DR SwissLipids; SLP:000001492; -.
DR PaxDb; Q94FY8; -.
DR PRIDE; Q94FY8; -.
DR EnsemblPlants; Zm00001eb237270_T003; Zm00001eb237270_P003; Zm00001eb237270.
DR GeneID; 541877; -.
DR Gramene; Zm00001eb237270_T003; Zm00001eb237270_P003; Zm00001eb237270.
DR KEGG; zma:541877; -.
DR MaizeGDB; 60529; -.
DR eggNOG; ENOG502QQ9P; Eukaryota.
DR OMA; FAFMYSI; -.
DR OrthoDB; 1312305at2759; -.
DR BRENDA; 5.5.1.24; 6752.
DR UniPathway; UPA00160; -.
DR Proteomes; UP000007305; Chromosome 5.
DR ExpressionAtlas; Q94FY8; baseline and differential.
DR GO; GO:0010287; C:plastoglobule; IEA:EnsemblPlants.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0009976; F:tocopherol cyclase activity; IEA:EnsemblPlants.
DR GO; GO:0015994; P:chlorophyll metabolic process; IEA:EnsemblPlants.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:EnsemblPlants.
DR GO; GO:0009915; P:phloem sucrose loading; IEA:EnsemblPlants.
DR GO; GO:0031347; P:regulation of defense response; IEA:EnsemblPlants.
DR GO; GO:0009644; P:response to high light intensity; IEA:EnsemblPlants.
DR GO; GO:0006979; P:response to oxidative stress; IEA:EnsemblPlants.
DR GO; GO:0009266; P:response to temperature stimulus; IEA:EnsemblPlants.
DR GO; GO:0010189; P:vitamin E biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016122; P:xanthophyll metabolic process; IEA:EnsemblPlants.
DR InterPro; IPR025893; Tocopherol_cyclase.
DR PANTHER; PTHR35309; PTHR35309; 1.
DR Pfam; PF14249; Tocopherol_cycl; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Isomerase; Plastid; Reference proteome; Transit peptide.
FT TRANSIT 1..65
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 66..474
FT /note="Tocopherol cyclase, chloroplastic"
FT /id="PRO_0000022562"
FT CONFLICT 188
FT /note="F -> L (in Ref. 1; AAK60502)"
FT CONFLICT 256
FT /note="S -> R (in Ref. 1; AAK60502)"
SQ SEQUENCE 474 AA; 52636 MW; D9C53BD310ED8E4E CRC64;
MNLAVAAALP SVTPRTGVVL PRSSRRHCPR GVVPRAASSS VSSFTSPSAA AAPIYTPTPQ
DRSLRTPHSG YHFDGTARPF FEGWYFKVSI PECRQSFCFM YSVENPLFRD GMSDLDKLLY
RPRFTGVGAQ ILGADDKYIC QFSEKSNNFW GSRHELMLGN TFISNKESTP PQGEVPPQDF
SRRVLEGFQV TPIWHQGFIR DDGRSNYVPN VQTARWEYST RPVYGWGDVK SKQLSTAGWL
AAFPFFEPHW QICMASGLST GWIEWDGERF EFENAPSYSE KNWGGGFPRK WYWIQCNVFP
GASGEVSLTA AGGLRKIGLG DTYESPSLIG IHYEGQFFEF VPWTGTVSWD IGLWGLWKMS
GENKTHLVEI EATTAESGTA LRAPTIEAGL VPACKDTCYG DLRLQLWEKK YDGSKGEMIL
DATSNMAALE VGGGPWFNGW KGTTVVNEVV NNIVGTPVDV ESLLPIPFLK PPGL
