ID   TODT_PSEPU              Reviewed;         227 AA.
AC   Q3LWR6; O07832;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Response regulator protein TodT;
GN   Name=todT; Synonyms=tobT;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PB4071;
RA   Li W., Tan H.M.;
RT   "Pseudomonas putida tobC2 (partial), tobB, tobA, tobD, tobE, tobG, tobI,
RT   tobH, tobS, tobT, tobU genes.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KL47;
RX   PubMed=16728956;
RA   Lee K., Ryu E.K., Choi K.S., Cho M.C., Jeong J.J., Choi E.N., Lee S.O.,
RA   Yoon D.Y., Hwang I., Kim C.K.;
RT   "Identification and expression of the cym, cmt, and tod catabolic genes
RT   from Pseudomonas putida KL47: expression of the regulatory todST genes as a
RT   factor for catabolic adaptation.";
RL   J. Microbiol. 44:192-199(2006).
CC   -!- FUNCTION: Member of the two-component regulatory system TodS/TodT
CC       involved in the regulation of toluene degradation. Phosphorylated TodT
CC       activates transcription of the tod operon (todXFC1C2BADEGIH) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by TodS. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABA10819.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF180147; AAG09418.1; -; Genomic_DNA.
DR   EMBL; DQ157469; ABA10819.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q3LWR6; -.
DR   SMR; Q3LWR6; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..227
FT                   /note="Response regulator protein TodT"
FT                   /id="PRO_0000423595"
FT   DOMAIN          28..142
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          158..223
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        182..201
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   MOD_RES         77
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   227 AA;  25432 MW;  7A5D506B9213E26D CRC64;
     MPARWGCLFP GKYPCQTGLR HMSDRASVIY ILDDDNAVLE ALSSLVRSIG LSVECFSSAS
     VFLNDVNRSA CGCLILDVRM PEMSGLDVQR QLKELGEQIP IIFISGHGDI PMAVKAIKAG
     AVDFFTKPFR EEELLGAIRA ALKLAPQQRS NAPRVSELKE NYESLSKREQ QVLKFVLRGY
     LNKQTALELD ISEATVKVHR HNIMRKMKVS SIQDLVRVTE RLKDSLE