TOE2_ARATH
ID TOE2_ARATH Reviewed; 485 AA.
AC Q9LVG2;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=AP2-like ethylene-responsive transcription factor TOE2;
DE AltName: Full=Protein TARGET OF EAT 2;
GN Name=TOE2; OrderedLocusNames=At5g60120; ORFNames=MGO3.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=14555699; DOI=10.1105/tpc.016238;
RA Aukerman M.J., Sakai H.;
RT "Regulation of flowering time and floral organ identity by a microRNA and
RT its APETALA2-like target genes.";
RL Plant Cell 15:2730-2741(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
CC -!- FUNCTION: Probably acts as a transcriptional activator. Binds to the
CC GCC-box pathogenesis-related promoter element. May be involved in the
CC regulation of gene expression by stress factors and by components of
CC stress signal transduction pathways (By similarity). Regulates
CC negatively the transition to flowering time and confers flowering time
CC delay. {ECO:0000250, ECO:0000269|PubMed:14555699}.
CC -!- INTERACTION:
CC Q9LVG2; F4K1A8: At5g26749; NbExp=3; IntAct=EBI-4424568, EBI-15191587;
CC Q9LVG2; O04292: ATHB-9; NbExp=3; IntAct=EBI-4424568, EBI-1536772;
CC Q9LVG2; O80748: B-box domain protein 26; NbExp=3; IntAct=EBI-4424568, EBI-15191535;
CC Q9LVG2; Q17TI5: BRX; NbExp=4; IntAct=EBI-4424568, EBI-4426649;
CC Q9LVG2; Q8W575: CSN3; NbExp=3; IntAct=EBI-4424568, EBI-531055;
CC Q9LVG2; Q94ID6: ERF12; NbExp=4; IntAct=EBI-4424568, EBI-4446727;
CC Q9LVG2; O80340: ERF4; NbExp=3; IntAct=EBI-4424568, EBI-966009;
CC Q9LVG2; Q9MAI5: ERF8; NbExp=3; IntAct=EBI-4424568, EBI-2000137;
CC Q9LVG2; Q9FE67: ERF9; NbExp=3; IntAct=EBI-4424568, EBI-4431933;
CC Q9LVG2; Q39103: GA3OX1; NbExp=4; IntAct=EBI-4424568, EBI-4426378;
CC Q9LVG2; Q9SQI2: GI; NbExp=3; IntAct=EBI-4424568, EBI-446380;
CC Q9LVG2; O24407: IAA16; NbExp=3; IntAct=EBI-4424568, EBI-632231;
CC Q9LVG2; O24410: IAA20; NbExp=3; IntAct=EBI-4424568, EBI-632272;
CC Q9LVG2; Q9C5X0: IAA34; NbExp=3; IntAct=EBI-4424568, EBI-3946459;
CC Q9LVG2; P92958: KIN11; NbExp=2; IntAct=EBI-4424568, EBI-307202;
CC Q9LVG2; P46639: KNAT1; NbExp=3; IntAct=EBI-4424568, EBI-530486;
CC Q9LVG2; P11035: NIA2; NbExp=3; IntAct=EBI-4424568, EBI-4451150;
CC Q9LVG2; Q8VZS8: PYL1; NbExp=3; IntAct=EBI-4424568, EBI-2363104;
CC Q9LVG2; Q8S8E3: PYL6; NbExp=3; IntAct=EBI-4424568, EBI-2363192;
CC Q9LVG2; Q84MC7: PYL9; NbExp=3; IntAct=EBI-4424568, EBI-2349513;
CC Q9LVG2; O82239: RFI2; NbExp=3; IntAct=EBI-4424568, EBI-4425094;
CC Q9LVG2; Q9M8Y0: SEC; NbExp=4; IntAct=EBI-4424568, EBI-4426966;
CC Q9LVG2; Q9LVG2: TOE2; NbExp=8; IntAct=EBI-4424568, EBI-4424568;
CC Q9LVG2; Q8H0Y8: WRKY41; NbExp=3; IntAct=EBI-4424568, EBI-15202502;
CC Q9LVG2; Q9FQ04: XRN4; NbExp=4; IntAct=EBI-4424568, EBI-25511549;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9LVG2-1; Sequence=Displayed;
CC -!- INDUCTION: Repressed by miR172a-2/EAT. {ECO:0000269|PubMed:14555699}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. AP2
CC subfamily. {ECO:0000305}.
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DR EMBL; AB019231; BAA96941.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97280.1; -; Genomic_DNA.
DR EMBL; BT001916; AAN71915.1; -; mRNA.
DR RefSeq; NP_200820.3; NM_125405.4. [Q9LVG2-1]
DR AlphaFoldDB; Q9LVG2; -.
DR SMR; Q9LVG2; -.
DR BioGRID; 21378; 88.
DR IntAct; Q9LVG2; 69.
DR STRING; 3702.AT5G60120.2; -.
DR PaxDb; Q9LVG2; -.
DR PRIDE; Q9LVG2; -.
DR ProteomicsDB; 234284; -. [Q9LVG2-1]
DR EnsemblPlants; AT5G60120.1; AT5G60120.1; AT5G60120. [Q9LVG2-1]
DR GeneID; 836134; -.
DR Gramene; AT5G60120.1; AT5G60120.1; AT5G60120. [Q9LVG2-1]
DR KEGG; ath:AT5G60120; -.
DR Araport; AT5G60120; -.
DR eggNOG; ENOG502R1D7; Eukaryota.
DR HOGENOM; CLU_035462_3_1_1; -.
DR InParanoid; Q9LVG2; -.
DR PhylomeDB; Q9LVG2; -.
DR PRO; PR:Q9LVG2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LVG2; baseline and differential.
DR Genevisible; Q9LVG2; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; DNA-binding; Ethylene signaling pathway;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..485
FT /note="AP2-like ethylene-responsive transcription factor
FT TOE2"
FT /id="PRO_0000290366"
FT DNA_BIND 160..216
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 124..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 53164 MW; BEFB290E407FC3D5 CRC64;
MLDLNLDVDS TESTQNERDS ITVKGVSLNQ MDESVTSNSS VVNAEASSCI DGEDELCSTR
TVKFQFEILK GGGEEEEEDD DERSAVMMTK EFFPVAKGMN FMDSSAQSSR STVDISFQRG
KQGGDFIGSG SGGGDASRVM QPPSQPVKKS RRGPRSKSSQ YRGVTFYRRT GRWESHIWDC
GKQVYLGGFD TAHAAARAYD RAAVKFRGLE ADINFVIGDY EEDLKQMANL SKEEVVQVLR
RQSSGFSRNN SRYQGVALQK IGGWGAQMEQ LHGNMGCDKA AVQWKGREAA SLIEPHASRM
IPEAANVKLD LNLGISLSLG DGPKQKDRAL RLHHVPNNSV CGRNTMMENH MAAAACDTPF
NFLKRGSDHL NNRHALPSAF FSPMERTPEK GLMLRSHQSF PARTWQGHDQ SSGGTAVAAT
APPLFSNAAS SGFSLSATRP PSSTAIHHPS QPFVNLNQPG LYVIHPSDYI SQHQHNLMNR
PQPPP
