TOF1_ASPCL
ID TOF1_ASPCL Reviewed; 1178 AA.
AC A1C928;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Topoisomerase 1-associated factor 1;
GN Name=tof1; ORFNames=ACLA_053980;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Forms a fork protection complex (FPC) with csm3 and which is
CC required for chromosome segregation during meiosis and DNA damage
CC repair. FPC coordinates leading and lagging strand synthesis and moves
CC with the replication fork. FPC stabilizes replication forks in a
CC configuration that is recognized by replication checkpoint sensors (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC tof1 and csm3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR EMBL; DS027048; EAW13352.1; -; Genomic_DNA.
DR RefSeq; XP_001274778.1; XM_001274777.1.
DR AlphaFoldDB; A1C928; -.
DR SMR; A1C928; -.
DR STRING; 5057.CADACLAP00005220; -.
DR PRIDE; A1C928; -.
DR EnsemblFungi; EAW13352; EAW13352; ACLA_053980.
DR GeneID; 4707118; -.
DR KEGG; act:ACLA_053980; -.
DR VEuPathDB; FungiDB:ACLA_053980; -.
DR eggNOG; KOG1974; Eukaryota.
DR HOGENOM; CLU_004390_0_0_1; -.
DR OMA; WLKLYDE; -.
DR OrthoDB; 839367at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
DR InterPro; IPR044998; Timeless.
DR InterPro; IPR006906; Timeless_N.
DR PANTHER; PTHR22940; PTHR22940; 1.
DR Pfam; PF04821; TIMELESS; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..1178
FT /note="Topoisomerase 1-associated factor 1"
FT /id="PRO_0000301728"
FT REGION 576..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..965
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1099
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 135716 MW; 2E86E4A0AF1323D0 CRC64;
MDDEGAPLSE SAQVVDPDVR AHVYSLVTAL GGFNGENADR YVLGDDALAC LRDIKRWLKL
HDEKNNRMDV ARCLGEANLV NGDLLPILTL WSTSGQNSKF MSRIALACLE LLVPLTWPLE
LHSEMTVNHH RHTPYLQQAQ VLYKRGILGP GGSSLLRTII RIGLPSMAVP RSDRTTRDEG
ILKLMLYLLR NIAVISPHSR LSAEGDEEET SRSATINAFQ DQDAFALLLT MCSNVADDFN
LQDVVLLEIL FHIVKGVNVE KLFMNDTQRK AKRTEELGDL LQKESSLRRE YAKNAPTRHG
RFGTMIWVKR DDAKVSTVSG QDVLKDSQTT LYKMDQSKKW NKPQVRRRQT EVTVNNDFNT
PVNLNSTATK NLRIFIEEFL DSGFNPLFTH VRKAIEREAD RIMDINSRHY FYTVAWFLEA
ERVRRKYQRE RHSQEDKSLK KMEPDSFALV ASVLNQETFV FLNRSMQKSF DNKEVEDLTA
EMRCFTQILL TVQEMAQSPL DDDQEVADNI QNRIFYEETT HDRIISIIRG YKDQGFGYLD
ACTQLAHVFL RMLEHYSKEN VDMQIRSRRR IKRKAKQDDQ AIDVEDEEHA SEDEELMEAE
RVSKERKFDF KRFAAKFCNQ KCVDTFVAFI KYYKELNTDQ LKRAHRYFYR IAFKQEMSVL
LFRLDIINLF YRMIKGPGAL DSSKPIFKEW EELVRQILRR MIKKIDQRPA LITELLFSKI
NSTVFYLEFG FEKQTISVSK RPPAELEVDP REAKTTDEKL SIVVRVMIKD EHINLVKWIS
EVLRLAADER ESWESREQQP GEPTAPNPMI PVKPDDEACQ KAMFSNAKLR LLMTLIGFER
LGMEDVPGAS WVVPSSFTSD DLRHTKRVID QCLIEPATED PDQDLSRLIR RKYANDARGG
GRDEQNLDID FGSDSEGEDN VPDGPLFPPN HRSKANALDQ LKKQRQKRRK EDGDRETPDD
EVLEERRRAR LENALARQAK IKSDLYIHAS DEESDEEADE EFFRLEEQRR KEQAARIKHA
LLHGVVEEIS DKSSKKTGRK RQSDQHTTLN IDAHTKRQRR KNRTDKLDEG DDLVMAGTEA
QSPDSPGLGS SSHDAKGIEN TPLTSDEDEL EFDDDLAFSR DRNRRKDFTP NVDKMVIEPA
QQDADPAAPD EDDDEDAPVV GSSRRRVRGG FVIESDSE
