ID   TOF1_ASPNC              Reviewed;        1169 AA.
AC   A2R2E3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Topoisomerase 1-associated factor 1;
GN   Name=tof1; ORFNames=An14g00440;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Involved in chromosome segregation during meiosis and DNA
CC       damage repair. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAK41843.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AM270309; CAK41843.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001400673.2; XM_001400636.2.
DR   AlphaFoldDB; A2R2E3; -.
DR   SMR; A2R2E3; -.
DR   PaxDb; A2R2E3; -.
DR   PRIDE; A2R2E3; -.
DR   EnsemblFungi; CAK41843; CAK41843; An14g00440.
DR   GeneID; 4986897; -.
DR   KEGG; ang:ANI_1_82124; -.
DR   VEuPathDB; FungiDB:An14g00440; -.
DR   Proteomes; UP000006706; Chromosome 1R.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR044998; Timeless.
DR   InterPro; IPR006906; Timeless_N.
DR   PANTHER; PTHR22940; PTHR22940; 1.
DR   Pfam; PF04821; TIMELESS; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1169
FT                   /note="Topoisomerase 1-associated factor 1"
FT                   /id="PRO_0000301730"
FT   REGION          573..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          900..1150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        970..998
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1011..1032
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1041..1074
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1109..1141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1169 AA;  134462 MW;  0FBED15D981A718D CRC64;
     MENEEPVLSA PDVQVVDPDV RAHVYSLVTA LGGFNGEDAD KYVLGDDALA CLRDIKRWLK
     LYDEKHNRMD VARCLGEANL VNGDLLPILA VWANSKKQTK YMSRIALACL ELLVPLTWPV
     ELHGELTINH HRHIPYIQHV HVSYKRGLLS HASTSYLRTI IRVGIPSMAI PRSERTTRDE
     GILKLLLYLL RNIALITPNT RLAAEGDEEE TSRSATINAF QDQDVFALLL TMCSNVGDDF
     TMQDVALLEI LFHLIRGVSV EKLFMDDAQR TAKRTDELDD LLRQESSLRR EYAKNAPTRH
     GRFGTMIWVK RDDAKYSTVS GQNVLKDGQA TLQKMDETKK WNKPLIRRKP QDLTVHNDFS
     TPVHLNSTAS NNLRMFVEEF LDSGFNPLLT HVRKAIEREA DRVMDINTRQ FLYTTAWFLE
     AERARRARQR KKHAESEKPA KELEPDSFGL VAGVLNQETF VFLNRAMQYA LDNKDWEDLN
     AGMRCFTQIL LTVQDMAQSP LEEDQEIAEN IQNRIFYEET THDRVLAVIR GYKDQPFGYL
     DACTELTHVF LRMLERYSKE NLDMQVRSRR RARRKAKDVE GTGNDENDEE NGSEDEDRLE
     AERVSKERKF DFRRFAAKFC NQKCVDTFVA FTKHYKELNT EQLKRAHRYF YRIAFKQELS
     VLLFRLDIIN LFYRMIKGPG ALDSSKPIFK EWEEFVRQII RRLTKRLDQR PALFVELLFS
     KINATTFYLE YGHERQTVTR ARKAPAELEI DPRQAHTIEE KISIMVPALV LDGEEDLVTW
     VSDVLESAVE EREAWETQEK ALRDAGAENS KIPNPMISVK ARDDACQQAM FSNAKLRLLM
     TLVKFERLGA EDVPGAAWII PSAPRAQDLR EMKSFIDKYF EKAKRGTLGR DPRELIRRKY
     GGGKTASDNQ HNPDIQFGDD SEGEDEVPDG PLFPPNPRAA PNPANKPTKK KKRKERNPDD
     EDEDDSVDEE TLEERRRARL ENSRARLAKI KSDLYVHASD EDTDEEGDKE FFLLEEQRRR
     EQAKRIKHAL LTGMTEDGDG STNKKGQRKR QTTRNRTGEA KSKRQRRGKQ ADEVDEDDDV
     VMGNMDAPSP MSDREGTPSG EEDDGFNFDD DLVFSRDREK LLGSAGNEEK DSNRPDKAMA
     QDEDDDDAPI VAANRRRMRA GFVVDSDSE