ID   TOF1_ASPOR              Reviewed;        1166 AA.
AC   Q2PIU8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Topoisomerase 1-associated factor 1;
GN   Name=tof1; ORFNames=AO090206000054;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Involved in chromosome segregation during meiosis and DNA
CC       damage repair. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR   EMBL; AP007172; BAE65426.1; -; Genomic_DNA.
DR   RefSeq; XP_001826559.1; XM_001826507.2.
DR   AlphaFoldDB; Q2PIU8; -.
DR   SMR; Q2PIU8; -.
DR   STRING; 510516.Q2PIU8; -.
DR   EnsemblFungi; BAE65426; BAE65426; AO090206000054.
DR   GeneID; 5998675; -.
DR   KEGG; aor:AO090206000054; -.
DR   VEuPathDB; FungiDB:AO090206000054; -.
DR   HOGENOM; CLU_004390_0_0_1; -.
DR   OMA; WLKLYDE; -.
DR   Proteomes; UP000006564; Chromosome 7.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR044998; Timeless.
DR   InterPro; IPR006906; Timeless_N.
DR   PANTHER; PTHR22940; PTHR22940; 1.
DR   Pfam; PF04821; TIMELESS; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1166
FT                   /note="Topoisomerase 1-associated factor 1"
FT                   /id="PRO_0000301731"
FT   REGION          333..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..594
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          881..981
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1023..1145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..353
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        881..912
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        942..981
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1032..1092
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1106..1145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1166 AA;  134300 MW;  1FD107BD03124B9E CRC64;
     MNDEAVAFSQ AVQVVDPDVR AHVYSLVTAL GGFNGEDADR YVLGDDALAC LRDIRRWLKL
     YDEKYHRMDV ARCLGEANLV NGDLLPIFSL WWSTGQKSKY MSRIALACLE LLVPLTWPLE
     VHGEMTVNHH RHFPYLQHAQ VSYKRGLLSR GDLNFLRTII RIGLPSMAVP RSERTTRDDG
     ILKLMLYLLR NIVVIAPNAR LAADGDEEET SRSATINAFQ AQDVFALLLT MCSNVGDDFN
     MQDVILLEIL FHLVKGVNVQ KLFMDDAQRS AKHTDELDTL LKQESSLRRE YAKNAPTRHG
     RFGTMIWVKR DDAKVSTVSG QDVLKDSQAT LQKMDESKKW NRPQPRKTHE DSVLNNDFST
     PAHLNSTASR NLRMFVEEFL DSGFNPLFTH VRKALEREAD RVVPINSRQF FYTVAWFLDA
     ERARRARQQE MHLQNGKPMK ELERDGFGLV ASVLDQETLV FLNRSMQISF DQKDWEDLNA
     EMRCFTQILL TVQEMTQSLL EEDQEIAENI QNRIFYEETT HDRVLAIMRE YKGQGFGYLD
     ACTELSHVFL RMLERYSKEN VDMQVRSRRR SRRKNMETQV AAPEDNNEEH ASDDEDIMEA
     ERICRERKFD FKRFAAKFCN QKCVDTFVAF TKFFRELNSD QLKRAHRYFY RIAFKQEMSV
     LLFRVDILNL FYTMIKGPGA MDSSKPIFKE WEELVRQVIR RMIKKIDQRP ALITELLFSK
     MNSTLFYLEY GHERQTLPSV RRAPAELEVN PSEATTQEDK IKIVIGALVM DGQADLVAWV
     SNVLGTAAEE RESWEAYEDA QRDEAQGAPR APNPMIAVLP HDDACKQAMY FNAKLRLLMT
     LVGFERLGME DVVGASWVVP SSQGSKDLKG IKLTIDKCLE DPYTGDIEHD PRQMLRRKYK
     PDDKEHNRQT TLDVDFGSES EGEDVPDGPL FPPNPRSKAN APNDSKTRRK NREAVGEREP
     IDEDTLEARR KARQENTRAR LAKIKSELFV HASDDESDEE ADKEFFDLEE KRRKEQAARV
     RKALLTGVVD EIGRKANKKS ERKRLSNSGK SDTQSKRQRR GRTTEALDED DDIIMDGAVA
     RSSDHATEDD ENTSATSDED DEFDFDDNLA FRRDRDLDRD PVLPSHAEDM QPTDTRELRD
     NDENAPVATL ARRRLRAGFV IDSDSE