TOF1_ASPTN
ID TOF1_ASPTN Reviewed; 1147 AA.
AC Q0CU99;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=Topoisomerase 1-associated factor 1;
GN Name=tof1; ORFNames=ATEG_02735;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Forms a fork protection complex (FPC) with csm3 and which is
CC required for chromosome segregation during meiosis and DNA damage
CC repair. FPC coordinates leading and lagging strand synthesis and moves
CC with the replication fork. FPC stabilizes replication forks in a
CC configuration that is recognized by replication checkpoint sensors (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC tof1 and csm3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR EMBL; CH476596; EAU37697.1; -; Genomic_DNA.
DR RefSeq; XP_001211913.1; XM_001211913.1.
DR AlphaFoldDB; Q0CU99; -.
DR SMR; Q0CU99; -.
DR STRING; 341663.Q0CU99; -.
DR PRIDE; Q0CU99; -.
DR EnsemblFungi; EAU37697; EAU37697; ATEG_02735.
DR GeneID; 4317034; -.
DR VEuPathDB; FungiDB:ATEG_02735; -.
DR eggNOG; KOG1974; Eukaryota.
DR HOGENOM; CLU_004390_0_0_1; -.
DR OMA; WLKLYDE; -.
DR OrthoDB; 839367at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
DR InterPro; IPR044998; Timeless.
DR InterPro; IPR006906; Timeless_N.
DR PANTHER; PTHR22940; PTHR22940; 1.
DR Pfam; PF04821; TIMELESS; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..1147
FT /note="Topoisomerase 1-associated factor 1"
FT /id="PRO_0000301732"
FT REGION 564..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..990
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1047
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 132551 MW; 4500FE6EA9E18C45 CRC64;
MDEELAFGQT VEVVDPDVRA HVYSLVTALG GFNGEDADKY VLGDDALACL RDIRRWLKLY
DEKYNRMDVA RCLGESNLVN GDLLPILSAW WHGNQGSRYM SRIALACKVE LLVPLTWPLE
VHAEMPANHL RHIPYLQHVQ VLYKRGLLSR GHTPLLRAII RIALPSMAVS RSERTTRDEG
ILKLMLYLLR NIAIISTNAR LAAEGDEEET SRSATINAFQ EQDAFALLLT MCSNVGDDFT
MQDMVLLEIV FHLIKGVDVE KLFMSDAQRS AKRTDELSEL LSKETSLRRE YAKNAPTRHG
RFGTMIWVKR DDAKMSTVSG QDVLKDSQAT LYKMDQSKKW NKPKQRQKQE LSVVNNDFDT
PVHLNPIASK NLRMFVEEFL DSGFNPLFTH VRKAIEREAD RVMDINSRQY FYAVAWFLEA
ERTRRVRQRE KHSQSEKAAK EFEPDSFSLI ASVLNQETFV FLNRSMQYSF DQKDWADLNA
EMRCFTQILL TVQEMATSPL EEDQEIAENI QNRIFYEETT HDRILAIVRG YKDQGYGYLD
ACTELSHVFL RMLERYSKEN TDMQIRSRRR AKRKKQLEQK GDENNGEEQD SEEEEMLEAE
RVSKERKFDF RRFSAKFCNQ KCVDTFVSFA RFYRELNSDQ LKRLHRYFYR IAFKEEMSVL
LFRVDIINLF YRMIKGPGGM DSTKPIFKEW EEFVRQLIRR MVKKIDQRPA LITEMLFSKI
NSTMYYLEFG HEKQTISVTR RPPAELVVNP NDAETTEDKI KIVIGALVKD GKNRLVSWLS
GVLDSAADER EAFEIQEAAE REENTRASRA PNPMIPVEPS DDDCKNEMFS NAKLRLLMAL
VKFERLGVED IPGASWVVPA HLSSADIRDI KSTVDKCLAD PFQGTFDREP QAMLQRKFQR
ENRGSFEPTQ EVSFGNDSEG EDTPEFLFPP NPRSKSNALE ELKKKRKKCK NDDGEKEPLD
EQTIEERRRA REENARSRQA KIKSDLYVHA SDEESDDEAD EEFFRLEEKR RKEQSERIRQ
ALLLGKVEEL ANKAGKKTQR KRPSDPQIAG DSESQNKRLR QDIPEDDDDL IMGGSEPDSP
GLQTGDHDSD DDLRFEDDLA FRRNRESSAA SDRNGPPGEA KEDEDTPVAA SGRRRMRAGF
VIDSDSE