ID   TOF1_ASPTN              Reviewed;        1147 AA.
AC   Q0CU99;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Topoisomerase 1-associated factor 1;
GN   Name=tof1; ORFNames=ATEG_02735;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with csm3 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       tof1 and csm3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR   EMBL; CH476596; EAU37697.1; -; Genomic_DNA.
DR   RefSeq; XP_001211913.1; XM_001211913.1.
DR   AlphaFoldDB; Q0CU99; -.
DR   SMR; Q0CU99; -.
DR   STRING; 341663.Q0CU99; -.
DR   PRIDE; Q0CU99; -.
DR   EnsemblFungi; EAU37697; EAU37697; ATEG_02735.
DR   GeneID; 4317034; -.
DR   VEuPathDB; FungiDB:ATEG_02735; -.
DR   eggNOG; KOG1974; Eukaryota.
DR   HOGENOM; CLU_004390_0_0_1; -.
DR   OMA; WLKLYDE; -.
DR   OrthoDB; 839367at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR044998; Timeless.
DR   InterPro; IPR006906; Timeless_N.
DR   PANTHER; PTHR22940; PTHR22940; 1.
DR   Pfam; PF04821; TIMELESS; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1147
FT                   /note="Topoisomerase 1-associated factor 1"
FT                   /id="PRO_0000301732"
FT   REGION          564..598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          799..823
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          898..1002
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1027..1147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        937..990
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1030..1047
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1083..1109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1116..1131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1147 AA;  132551 MW;  4500FE6EA9E18C45 CRC64;
     MDEELAFGQT VEVVDPDVRA HVYSLVTALG GFNGEDADKY VLGDDALACL RDIRRWLKLY
     DEKYNRMDVA RCLGESNLVN GDLLPILSAW WHGNQGSRYM SRIALACKVE LLVPLTWPLE
     VHAEMPANHL RHIPYLQHVQ VLYKRGLLSR GHTPLLRAII RIALPSMAVS RSERTTRDEG
     ILKLMLYLLR NIAIISTNAR LAAEGDEEET SRSATINAFQ EQDAFALLLT MCSNVGDDFT
     MQDMVLLEIV FHLIKGVDVE KLFMSDAQRS AKRTDELSEL LSKETSLRRE YAKNAPTRHG
     RFGTMIWVKR DDAKMSTVSG QDVLKDSQAT LYKMDQSKKW NKPKQRQKQE LSVVNNDFDT
     PVHLNPIASK NLRMFVEEFL DSGFNPLFTH VRKAIEREAD RVMDINSRQY FYAVAWFLEA
     ERTRRVRQRE KHSQSEKAAK EFEPDSFSLI ASVLNQETFV FLNRSMQYSF DQKDWADLNA
     EMRCFTQILL TVQEMATSPL EEDQEIAENI QNRIFYEETT HDRILAIVRG YKDQGYGYLD
     ACTELSHVFL RMLERYSKEN TDMQIRSRRR AKRKKQLEQK GDENNGEEQD SEEEEMLEAE
     RVSKERKFDF RRFSAKFCNQ KCVDTFVSFA RFYRELNSDQ LKRLHRYFYR IAFKEEMSVL
     LFRVDIINLF YRMIKGPGGM DSTKPIFKEW EEFVRQLIRR MVKKIDQRPA LITEMLFSKI
     NSTMYYLEFG HEKQTISVTR RPPAELVVNP NDAETTEDKI KIVIGALVKD GKNRLVSWLS
     GVLDSAADER EAFEIQEAAE REENTRASRA PNPMIPVEPS DDDCKNEMFS NAKLRLLMAL
     VKFERLGVED IPGASWVVPA HLSSADIRDI KSTVDKCLAD PFQGTFDREP QAMLQRKFQR
     ENRGSFEPTQ EVSFGNDSEG EDTPEFLFPP NPRSKSNALE ELKKKRKKCK NDDGEKEPLD
     EQTIEERRRA REENARSRQA KIKSDLYVHA SDEESDDEAD EEFFRLEEKR RKEQSERIRQ
     ALLLGKVEEL ANKAGKKTQR KRPSDPQIAG DSESQNKRLR QDIPEDDDDL IMGGSEPDSP
     GLQTGDHDSD DDLRFEDDLA FRRNRESSAA SDRNGPPGEA KEDEDTPVAA SGRRRMRAGF
     VIDSDSE