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TOF1_CANGA
ID   TOF1_CANGA              Reviewed;        1176 AA.
AC   Q6FNX7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Topoisomerase 1-associated factor 1;
GN   Name=TOF1; OrderedLocusNames=CAGL0J08250g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with CSM3 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       TOF1 and CSM3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR   EMBL; CR380956; CAG61018.1; -; Genomic_DNA.
DR   RefSeq; XP_448067.1; XM_448067.1.
DR   AlphaFoldDB; Q6FNX7; -.
DR   SMR; Q6FNX7; -.
DR   STRING; 5478.XP_448067.1; -.
DR   PRIDE; Q6FNX7; -.
DR   EnsemblFungi; CAG61018; CAG61018; CAGL0J08250g.
DR   GeneID; 2889924; -.
DR   KEGG; cgr:CAGL0J08250g; -.
DR   CGD; CAL0129427; CAGL0J08250g.
DR   VEuPathDB; FungiDB:CAGL0J08250g; -.
DR   eggNOG; KOG1974; Eukaryota.
DR   HOGENOM; CLU_008440_0_0_1; -.
DR   InParanoid; Q6FNX7; -.
DR   OMA; WLKLYDE; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0031298; C:replication fork protection complex; IEA:EnsemblFungi.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:EnsemblFungi.
DR   GO; GO:0043570; P:maintenance of DNA repeat elements; IEA:EnsemblFungi.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; IEA:EnsemblFungi.
DR   GO; GO:0043111; P:replication fork arrest; IEA:EnsemblFungi.
DR   GO; GO:0048478; P:replication fork protection; IEA:EnsemblFungi.
DR   InterPro; IPR044998; Timeless.
DR   InterPro; IPR006906; Timeless_N.
DR   PANTHER; PTHR22940; PTHR22940; 1.
DR   Pfam; PF04821; TIMELESS; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1176
FT                   /note="Topoisomerase 1-associated factor 1"
FT                   /id="PRO_0000301734"
FT   REGION          375..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          915..949
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          974..998
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1148..1176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..390
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        915..931
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1155..1176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1176 AA;  135249 MW;  27C925FDEBE21EC6 CRC64;
     MSDTESPLTV LKARIALLAT AIGGPDYTSQ IDPPPYQIGD DCLACLKDLK RWFRLVDDNQ
     RRWDVAMAVA EYKILTDDLL PILIDWENKC YLATKLSKGN SDISAHFKNK QYYDKIALNC
     LQLMVLMTWP LILTEQSSTN QINLYSELKK HQLTYKKAIL SVENGKVLKA AIRIAIDVIK
     LDRLARTPRD NMVLKMVLNF IRNILAIEPG ELTITARKNI ASKGINSVDT LPPNVTQDDI
     SQSTVISCFK KNKVFPFLLT LGSSMTKEFD QDFINIPLME VMFFLTKDIS QDSLLFKSGE
     LDTAQSENHL SKAGQELNDL LQKESQLKKK VIMNTSTRHS RFGAMLSIQT LDQKRLTVSG
     SQNLLDNSKA LQKIDDSKKS KGRRPMIRNE TDNESLPTNL LNVHKKSGTY LPLTISKYLN
     DFINDFIDSS FNYLLKSVTN YFVTEEDKII SLEKIEYLLF FAWFNKYQIL RCQVDKDADI
     MMISESIKET TFILVSSLLR SSYDSKAWAV VHSSMLAFNE LLKLVNSLKK FEDNEDIEYV
     LSRLFSDERI QLLSNLPRIA STHSLSFMKT SIELTHTVLK ILEMYSGDNS LVVESKRRAK
     KMKSISKEDY ERLVNEEGYD PDEAIEILNP GHKTIVINFK RVQSSFFHRN TIDLYINTLK
     RFNELEYSHI KMIISFLYRL FVENNEETLF YRLDFIILLK DMLKQDGLPR TSKARTHIND
     FAKYYLSRLK RKLKSSPAWH VGILFPPLND GVVGYFQKYG EHKMTKESEI YAVQPSQFIP
     FEQQEMMSEN MILDMQIGVL VSTLIDEGSQ NLVELVRENV QHLIAVFTSH LEVAGENEKT
     PNNEAFILKE EYDVNPLHYN RHIRALLQLV GFEIPILKSD PCFYRGTTEF SRLVKCEESI
     TKYLNIPFET PNGLPSSSYL KQQSEKNNSL ESDGWKGNED YDYTDPNIVP DNEVDDNDYF
     KDLDKSTNIR KEKRTVGIAS KKTQSKNKTS RNRKKASFRL PNAIEGKDKQ PQENLEVFSK
     EYISDSDEDD EEILNPVFFE NEMYMRWLLD KYNGQLPNDK FLSFGRFVNE RLSNNGKVVS
     DFTSLFDGPV PPIDALPLEG ITRKGPDKTL LTLSRVEINE SNQDNENTQV NEQVDETSEN
     LTINKNARNI GISHGHVESE ADDDEPITKK RRTSAN
 
 
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