TOF1_EMENI
ID TOF1_EMENI Reviewed; 1167 AA.
AC Q5AXH3; C8VC91; Q9Y8F5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Topoisomerase 1-associated factor 1;
GN Name=tof1; Synonyms=mdrA; ORFNames=AN7007;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Cheong C., Kang H.-S.;
RT "Cloning, sequencing, and functional analysis of mdrA, an Aspergillus
RT nidulans drug resistance gene.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Involved in chromosome segregation during meiosis and DNA
CC damage repair. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD41625.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CBF79271.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA61653.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF072683; AAD41625.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AACD01000117; EAA61653.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001304; CBF79271.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_664611.1; XM_659519.1.
DR AlphaFoldDB; Q5AXH3; -.
DR SMR; Q5AXH3; -.
DR STRING; 162425.CADANIAP00000469; -.
DR PRIDE; Q5AXH3; -.
DR EnsemblFungi; EAA61653; EAA61653; AN7007.2.
DR GeneID; 2870083; -.
DR KEGG; ani:AN7007.2; -.
DR eggNOG; KOG1974; Eukaryota.
DR HOGENOM; CLU_004390_0_0_1; -.
DR InParanoid; Q5AXH3; -.
DR OrthoDB; 839367at2759; -.
DR Proteomes; UP000000560; Chromosome IV.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR GO; GO:0048478; P:replication fork protection; IBA:GO_Central.
DR InterPro; IPR044998; Timeless.
DR InterPro; IPR007725; TIMELESS_C.
DR InterPro; IPR006906; Timeless_N.
DR PANTHER; PTHR22940; PTHR22940; 1.
DR Pfam; PF04821; TIMELESS; 1.
DR Pfam; PF05029; TIMELESS_C; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..1167
FT /note="Topoisomerase 1-associated factor 1"
FT /id="PRO_0000301739"
FT REGION 332..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1105..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..969
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1062
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 635
FT /note="E -> V (in Ref. 1; AAD41625)"
FT /evidence="ECO:0000305"
FT CONFLICT 1016
FT /note="L -> C (in Ref. 1; AAD41625)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1167 AA; 134367 MW; 3234327D27F1BA6A CRC64;
MEEAVPAQTV EVIDPEVRAH VYSLLGGFNG EDADKYVLGD DALSCLRDIK RWLKLYDEKF
NRMDVARCLG EANLVNGDLI QILSLWWREG QQSKYMTRIA LACVELLVPL TWPLEIHGEM
TVNHHRHIPY LQQAQVGYKR GILNMASCGI LRAVIRIGLP SMAIPPSERT ARDEGILKIM
LYLLRNIAII TANARLAAEG EEEETSRSAT INAFHDQDVF ALLLTLCSNV SDDFNMLDIP
LLEILFHMVR GIDVEKLFMN DAQRSAKRTD ELNDLLRQES SMRREYAKNA PTRHGRFGTM
IWVKRDDAKM STVSGQDVLR DEQTTLYKMD QSKRWNKPRR GRKAQDMSVN NDFNTPVHIS
PSATTNLRMF VEEFLDSGFN PLFVHVRKAI ERESIRVLDI NKRHFLYTVS WFLGAERARR
ARQREKYAQS GKKPDNELEP DSFGLVAGVL NQETFVFLNR SMQNSLDNKE WDDLNAAMRC
FTQILLTVQE MSQSPLEEDQ EIAENIQNRI FYEETTHDRI LAILRGYTDQ GFGYLDACTE
LSHVFLRMLE RYSKTNVDMQ VRSRRRARKR KREEQLVNKG SDEEQESEDE DYAEAEKMSK
ERKFDFTRFA AKFSNQKCVD TFVAFTKFYK ELNNEQLKRA HRYFYRIAFK QEMTVLLFRV
DILNLFYRII KGPGGMDSSK PIYKEWEELV RQLIRRLIKK LEQRPALITE LLFSKINSTA
FYLEYGFEKQ TVTTSKRAPA ELEVDPKAAS TPEEKLSIVV AALVKDEQSA LVKWISEVLG
SAADEREAWE LNSHDVDLAG PRDTQNPIIT VKSQDNSFKR AMFQNAKLRL LMTLLKFDRL
GQENVEGISW IIPSELKSDE LRESKAVIDK ALLIGNTDER DPNDLLRKKY SHEPRDGFSG
QNLDVNFGSD SEGEDVIPDG PLFPANPRSK AHALNELKQK RKKRKDKGEE EPVDEETLEE
RRQARLENTR WRLAKIKSDL YVHASDEESD AEADQEFFRL EEERRNEQSE RIKKALLLGR
TEDAGNKARQ RKRGKRSNEP NIAGEEETSG KRRRHSGGTN VELEEDDILM DDMEMPSRAS
SGEYSSNDAD AIDKSMAAAE DELYFDDDLA FGRDRDKDET SVDRDGADAS SPRKHNDGSE
SAEEDIPLAP PNRRRLRAGF VVESDSE
