TOF1_MAGO7
ID TOF1_MAGO7 Reviewed; 1214 AA.
AC A4R4R3; G4NGY5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Topoisomerase 1-associated factor 1;
GN Name=TOF1; ORFNames=MGG_03991;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
CC -!- FUNCTION: Forms a fork protection complex (FPC) with CSM3 and which is
CC required for chromosome segregation during meiosis and DNA damage
CC repair. FPC coordinates leading and lagging strand synthesis and moves
CC with the replication fork. FPC stabilizes replication forks in a
CC configuration that is recognized by replication checkpoint sensors (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC TOF1 and CSM3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR EMBL; CM001236; EHA47495.1; -; Genomic_DNA.
DR RefSeq; XP_003719862.1; XM_003719814.1.
DR AlphaFoldDB; A4R4R3; -.
DR SMR; A4R4R3; -.
DR STRING; 318829.MGG_03991T0; -.
DR PRIDE; A4R4R3; -.
DR EnsemblFungi; MGG_03991T0; MGG_03991T0; MGG_03991.
DR GeneID; 2677242; -.
DR KEGG; mgr:MGG_03991; -.
DR VEuPathDB; FungiDB:MGG_03991; -.
DR eggNOG; KOG1974; Eukaryota.
DR HOGENOM; CLU_004390_0_0_1; -.
DR InParanoid; A4R4R3; -.
DR OMA; WLKLYDE; -.
DR OrthoDB; 839367at2759; -.
DR Proteomes; UP000009058; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
DR InterPro; IPR044998; Timeless.
DR InterPro; IPR006906; Timeless_N.
DR PANTHER; PTHR22940; PTHR22940; 1.
DR Pfam; PF04821; TIMELESS; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..1214
FT /note="Topoisomerase 1-associated factor 1"
FT /id="PRO_0000301742"
FT REGION 316..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 894..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..944
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1094
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1214 AA; 137298 MW; 5F5773B876F1E443 CRC64;
MEASDGSNDV VHPEVRAHIN SLVSALGGFS ADDDGRYKLG DDALEVLRDM KKWIRFYDEK
TNRMDVARCL SEANVVGGDL LQILATWPEA QSDSKFKARV ALACYEIMTP LTWPIEKDPE
RTTVNHYRHM PVLQLAQLGY KRDIINFDGA QILHTAIRVA LPSMAVPIGD RTPRDQGIIK
LVLYFLRNIA MIAPPPGLKY DGDESQISRS ATIDAFSYQD IFLAILTIAS NMGEDFRTED
VIIMEIIFHL VKRVDIRKLF LDGEALSKAK GEDLVALIKK EKSMLRAQNK RAPTRHNRFG
TMVWVQRADG RMSAISGQDA LRDSATRERK MDDSKTFRPP RRSRKAEMEP KDLGSPVSLN
ERANKQLRGF VEEFLDSGFN PLFQHIRKTI DREAPYLLHQ HRAQFFYLTA WFLQAERERI
KTAKNQGSST TQDDVSPFNL VAGVLNQEMF ITLSRAMDRA YNDKDWPELT TVMRCFSQIL
LTVQDMADSG DEENEDIAEN ILNRLFYEEA THDAIANIAR NFKDQGFEYL DACTELIHTY
LRILESYSKQ NVDMQVRSRK RTRKKKKAAK ATGEDGDPVD DTRIDDGDDS ANDEASAERT
SRERKFDFGR FAMRFVPQGV VDTFVQFTKY YRDLDDSQLK RAHRYFFRVA FKQDMSVMLF
RVDIIHLLYN MIKGPEALDK SSSMFKDWEE LVKQIIRKCV RKIEDRPALI IEMLFSKINS
TAHYLEFGFE KQTISGSANP RPGAELEFKK QDLNLEQQIA IAVGVLLDKN QADHLTWVKN
VLSNAEVERR AWETAQDALP SVESQNVEGD IENEAPAASS IPQDSTPTIV RPDHDGRRGA
MFKNPHLRLL MRLVGFERLA PSEAETPESA WIIPANLRAD QLQEAVGHIN AAEFNPPVFD
DDKSAEDQLR RKSAGTTSRR KKAAFDDDEE NDVDNEDDDG LEEFLFEPGG PTARKSDVRP
KKKLTRRKRS PGQELTDEQQ DEKARLRREK DLEKQRKIKS AARVHSSDEE SDQEADAAFF
AREKERMAAR NALYSRLARN PGEFAAEKAA GKTTKVPVLL SDESGGEDSV AAAERSKRRK
RKSESVAGDE DDRDGGSDGG SEDAGTPARD APETKPLPKR RKKATAFVVS SDEEDSGDEA
PANTRGQSSQ RSAAEDAMET DETPLSSSPH KTKTTDVEMA NDDDHDEEDT PVKAPTQRRP
RAKAGFVLDS SDEE