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TOF1_NEOFI
ID   TOF1_NEOFI              Reviewed;        1177 AA.
AC   A1D9I5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Topoisomerase 1-associated factor 1;
GN   Name=tof1; ORFNames=NFIA_028970;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with csm3 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       tof1 and csm3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR   EMBL; DS027693; EAW20466.1; -; Genomic_DNA.
DR   RefSeq; XP_001262363.1; XM_001262362.1.
DR   AlphaFoldDB; A1D9I5; -.
DR   SMR; A1D9I5; -.
DR   STRING; 36630.CADNFIAP00002719; -.
DR   PRIDE; A1D9I5; -.
DR   EnsemblFungi; EAW20466; EAW20466; NFIA_028970.
DR   GeneID; 4589179; -.
DR   KEGG; nfi:NFIA_028970; -.
DR   VEuPathDB; FungiDB:NFIA_028970; -.
DR   eggNOG; KOG1974; Eukaryota.
DR   HOGENOM; CLU_004390_0_0_1; -.
DR   OMA; WLKLYDE; -.
DR   OrthoDB; 839367at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR044998; Timeless.
DR   InterPro; IPR006906; Timeless_N.
DR   PANTHER; PTHR22940; PTHR22940; 1.
DR   Pfam; PF04821; TIMELESS; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1177
FT                   /note="Topoisomerase 1-associated factor 1"
FT                   /id="PRO_0000301743"
FT   REGION          575..597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          791..815
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          874..1001
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1021..1177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        800..815
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        885..909
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        962..977
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1021..1047
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1057..1078
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1082..1103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1116..1135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1138..1155
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1177 AA;  134953 MW;  F98C8138F7947ACC CRC64;
     MDEEGAPLSE SVQVVDPDVR AHVYSLVTAL GGFNGESADR YVLGDDALAC LRDIKRWLKL
     YDEKNNRMDV ARCLGEANLV NGDLLPILTL WSTSGQKSKH MSRIALACLE LLVPLTWPLE
     VPSKMTVNHH RHTPYLQQAQ VLYKRGILSH GSDSILRTII RIGLPSMAVP RSERTTRDEG
     ILKLMLYFLR NIAVISPNAR LAAEGDEEET SRSATINAFQ NQDAFALLLT MCSNVGEDFS
     LQDVVLLEIL FHIVKGVNVE KLFMNDAQRK AKRTDELGEL LQKESSLRRE YAKNAPTRHG
     RFGTMIWVKR DDAKVSTVSG QDVLKDSQTT LHKMDQSKKW NKPQIRRRAA EVTANNDFNT
     PVNLNSTATK NLRMFVEEFL DSGFNPLFTH VRKAIEREAD RVLDINTRQF FYTVAWFLEA
     ERVRRAHQRE KRHLGDKSLN EIEPDSFALV ASVLNQETFV FLNRSMQYSY DNKDVEDLTA
     EMRCFTQILL TVQEMAQSPL EEDQEIADNI QNRIFYEETT HDRIIAIVRG YKDQGFGYLD
     ACTELAHVFL KMLEHYSKEN VDMHIRSRRR AKRKAKQAKQ ADIEGDDEEQ ASEEEDLMDA
     ERISKERKFD FKRFAAKFCN QSCVDTFIAF TKYYKELNVD QLKRAHRYFY RIAFKQEMSV
     LLFRLDIINL FYRMIKGPGA LDSNKPIFKE WEELVRQIIR RMVKKIDQRP ALITELLFSK
     INSTVFYLEY GHEKQTISAS KRPPAELEVD PREAKTTDEK IKIVVHVMVK DEHTDLVKWV
     SDVLNSAADE REAWESQEQH SEGQKAPNPM IPVKSNNESC QKAMFSNAKL RLLMTLVRFE
     RLGMEDVPGA SWIVPSSLTS QDLRHTRSMI EQCLTEPVTE SSDRDLSQLI RRKSGNNTRR
     DRDDQTADVD FGSDSEGDDN VPDGPLFPPN PRSRASALEQ LKKQRKKRRK QAGEEEEPDE
     EDLEGRRRAR LENALARQAK IKSDLYIHAS DEQTDEEADQ EFFRLEEQRR KEQAERIRKA
     LLHGVVEEAS ENSRKKGSGR KRQSDQHTAS TADSQSKRQR RQQRTGGLDD DDDLVMTGTD
     ARSPDSLGQG SPSLQGANDV EDTPVTSEEN ELDFDDDLAF SRNRNRDKVL SAENDDSDTE
     PPAPDTIDED DDDEAAPVAA PPRRRMRAGF VIESDSE
 
 
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