TOF1_PHANO
ID TOF1_PHANO Reviewed; 1177 AA.
AC Q0UJF3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Topoisomerase 1-associated factor 1;
GN Name=TOF1; ORFNames=SNOG_08111;
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
CC -!- FUNCTION: Forms a fork protection complex (FPC) with CSM3 and which is
CC required for chromosome segregation during meiosis and DNA damage
CC repair. FPC coordinates leading and lagging strand synthesis and moves
CC with the replication fork. FPC stabilizes replication forks in a
CC configuration that is recognized by replication checkpoint sensors (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC TOF1 and CSM3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR EMBL; CH445336; EAT84387.1; -; Genomic_DNA.
DR RefSeq; XP_001798436.1; XM_001798384.1.
DR AlphaFoldDB; Q0UJF3; -.
DR SMR; Q0UJF3; -.
DR STRING; 13684.SNOT_08111; -.
DR EnsemblFungi; SNOT_08111; SNOT_08111; SNOG_08111.
DR GeneID; 5975334; -.
DR KEGG; pno:SNOG_08111; -.
DR eggNOG; KOG1974; Eukaryota.
DR HOGENOM; CLU_004390_0_0_1; -.
DR InParanoid; Q0UJF3; -.
DR OMA; WLKLYDE; -.
DR OrthoDB; 839367at2759; -.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR GO; GO:0048478; P:replication fork protection; IBA:GO_Central.
DR InterPro; IPR044998; Timeless.
DR InterPro; IPR006906; Timeless_N.
DR PANTHER; PTHR22940; PTHR22940; 1.
DR Pfam; PF04821; TIMELESS; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..1177
FT /note="Topoisomerase 1-associated factor 1"
FT /id="PRO_0000301745"
FT REGION 332..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..923
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..1000
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1177 AA; 134137 MW; 28B90431C5291508 CRC64;
MAQTTLDDWA KDPVDPEIRA HVHSLITALG GIGDDGTYSL GDDALLCLKD LRKWLKFGDG
QLNRRDVARC MAEANLVKGD LLEILAKISP KAIEDKWRHK IAVAALELLV PLTWPFEIDP
IEATVNHHRH GPYIQLAQIG YKRAILQFDR DRTLQTAVKI ALPSMAVPLR ERTPRDEGII
RIALYFIRNI AMLSPPTSAP MDIDEAEVSR SATIDTFHEQ DIFQVLLSVA SSIGEDFVAQ
DVIVLEILFF LLKGIDAEKL FMEDKKLGTK NADELKNLMQ KEKAMLAGYA RNAPTRHNRF
GTMIWVKRDD EKVTTISGQD VLGKAQASMQ KMDQTKKWNK PRRPGKKVDG EQEREEFDLP
VALTVSARKH IKAFVEEFLD SSFNPLFLHL RKAIERETER VEIRHSRQFF YLASWFLRAE
CARRRTMKER AADPKDPAVL TAEDESYGLV AEVMNQETFI LLNRFMQKSQ DEKAWQDLNA
GMKCFTQILL TVHEMSESAL EDDQEIAENI QNRIFYEEST HDRVVMILRS YNGQGFGYLD
AVTELSHVFL RMLERYAKQN VDLQVKSKRR ARKIKKKVAE THGANGDEEG QVSDTEDIQQ
AQRTVSERKF DFQRFAAKFV NQSSVDTFVA FARYFSDLDT EQLKRIHRFF HRVAFKMELG
VLLCRVDILQ LFTKMMKGPG GLDPESPAYK EWDEFVRHFF RQVVKKVQER PELVVEMLFS
KIPATLFFLD HGYDREITKS TPRAPAELEV KPGMEVPEQI GVAVGVLINQ AKSDALHWVR
DILISAAEER KAWEGAEEAR KALAAAERPA GEEVAENTEE ESPKPPSILV KPDSEERRLA
MFKDNKLRLL MTLVGFSRLG EAHDPDATWI IPSAFTSTDL EFAIDLLRKY EFDPPTYEDG
KGPEDLIRNK ASAARRSTRR VDFDDDDEEA ENAVEEDHGE YRAGKATERK PDGERKKLKR
RQRVGTPVEL DDEEKDRRAE ARRKKELEKF AKQKSTEFVH DSDEEDDDDK DMEFFRREEA
LRTEIMKAFG KSLTAGSTET ATSKKRKAED STSRTKRRKT PPKRKAQPFA DSDDSDEDVQ
DAATPSSRAP SLSARDMIHD ESEVEDEATD TPLSSQHANG VHESDEDTTT GATASITVKS
QDVVMADDDD EEDEATPVAR RPMARKRGAF IVDSDSE
