TOF1_USTMA
ID TOF1_USTMA Reviewed; 1251 AA.
AC Q4PAB2; A0A0D1DZF4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Topoisomerase 1-associated factor 1;
GN Name=TOF1; ORFNames=UMAG_02951;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in chromosome segregation during meiosis and DNA
CC damage repair. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR EMBL; CM003146; KIS68971.1; -; Genomic_DNA.
DR RefSeq; XP_011389355.1; XM_011391053.1.
DR AlphaFoldDB; Q4PAB2; -.
DR SMR; Q4PAB2; -.
DR STRING; 5270.UM02951P0; -.
DR PRIDE; Q4PAB2; -.
DR EnsemblFungi; KIS68971; KIS68971; UMAG_02951.
DR GeneID; 23563565; -.
DR KEGG; uma:UMAG_02951; -.
DR VEuPathDB; FungiDB:UMAG_02951; -.
DR eggNOG; KOG1974; Eukaryota.
DR HOGENOM; CLU_004294_0_0_1; -.
DR InParanoid; Q4PAB2; -.
DR OMA; MHRIAIK; -.
DR OrthoDB; 839367at2759; -.
DR Proteomes; UP000000561; Chromosome 7.
DR GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR GO; GO:0048478; P:replication fork protection; IBA:GO_Central.
DR InterPro; IPR044998; Timeless.
DR InterPro; IPR006906; Timeless_N.
DR PANTHER; PTHR22940; PTHR22940; 1.
DR Pfam; PF04821; TIMELESS; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..1251
FT /note="Topoisomerase 1-associated factor 1"
FT /id="PRO_0000301748"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1089
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1139
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1251 AA; 141410 MW; 56B5EC32D8E2A1BD CRC64;
MATKDDYSED LENDADLMTD FSDDEYGYRH EEGHNDEEAA PNIEEIREAA ADLCNQIGEY
DYGDEHDWDG EQYPRLKRWK HRPRALGSLR SLRKLWKMDD DDPTRKVARA FAENEVLQHT
ILPALLESAG QGKEGDAIAL ACTDLLTAMT WPFDGLEELR EQEKQGHLDL AELSEITLLD
EHLVNYKSVI LRNRSLDQQH DVLGVVMRYL LLPNLATKHH ERSTLATGII SMCLHLFRNL
LAIRDPVTTS LSSVERLSNA NLQSELILSM HKHHILDALL MLSSSAETQA YNAWNAVASE
CIFHIFVGTM VKTIAEPTFS GSGTRMSHDS TPNASASNTA GSSSNANAGP ISSLAESLAM
ETKLKRASAS GKIATRHSRF GTTINFVGPD GELRVARNQA ALIKPVAQLA DEANQKGRRR
AQRRKDAQEK GAPKLKSKWT PDAALVLQEW ADTFVQSGFE PLAKSVLKDI RSERDKLGDL
DVARVRIMQL GAFFLEYFLL RRTTAAKRRN AAKTAGSVQS TFAQRALDLQ EPDEQHERSG
QSAEQPEEAE EWPFELVSQW LEPWAFRMVL VRTIQSQETK AWLEFVASVR LWIVLLRLVD
ELANSKKESE RDVAEGLQAE FYYMGETLEA CHAIFRSYTT QSFAFLDAII AFAYVMPKML
ERYASNRDHM YVQAKKQVHR SRQDGDLDTD QDEARQIKEQ LQETRSEREF RFADFQRKLA
TKQLAKACIV YLRRWKDNNG TEDQLNELVT VMHRIAIKAN DYRQFFLATH RDYLRFMISG
DTISAFEARA PTSAPNLRKL IDYILRKFSK LSPEEQSIYN AGKQPTRQPK PPRMPAEIVV
RPGMTPDQEI GVAVGLLLKK EKMPAVLWIK SALEMASAMR TELVLRYEEE EAQRSIQGAG
DDMMLLGELE KHNESPVERF QPYELAYHGN DELRTDASLM PELKLLCRLV GLEANDNELV
NWRWSVPKEI LPVHLDQKIE TIERYIREPL DTHGRELTAL VMRIRKPRVA GEADADVLDP
ADLPDGWNGA QSDSDEDGDY FDRIRASRSL VSADHVAAEG GLLRRSGPKK KLSHPTKGDG
SRKKKQIQRI KQDIIDDSDD EFAFALADLQ PQARTDADAD SSSDDKEEED DDDDNMDDQE
TPATSSVADL QEQFDQGKSN ALDALRTAKQ QRSNTEQPPL QDAGERINRR MDTKRLFLAD
SDEDDDDVLA LSSQEPADIS ATSDRTATGP SVWAGIAKKR RLAILDDEDE D
