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TOF1_YARLI
ID   TOF1_YARLI              Reviewed;        1054 AA.
AC   Q6CFJ2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Topoisomerase 1-associated factor 1;
GN   Name=TOF1; OrderedLocusNames=YALI0B06512g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with CSM3 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       TOF1 and CSM3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
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DR   EMBL; CR382128; CAG82801.1; -; Genomic_DNA.
DR   RefSeq; XP_500570.1; XM_500570.1.
DR   AlphaFoldDB; Q6CFJ2; -.
DR   SMR; Q6CFJ2; -.
DR   STRING; 4952.CAG82801; -.
DR   PRIDE; Q6CFJ2; -.
DR   EnsemblFungi; CAG82801; CAG82801; YALI0_B06512g.
DR   GeneID; 2907602; -.
DR   KEGG; yli:YALI0B06512g; -.
DR   VEuPathDB; FungiDB:YALI0_B06512g; -.
DR   HOGENOM; CLU_004390_0_0_1; -.
DR   InParanoid; Q6CFJ2; -.
DR   OMA; MHRIAIK; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR   GO; GO:0048478; P:replication fork protection; IBA:GO_Central.
DR   InterPro; IPR044998; Timeless.
DR   InterPro; IPR006906; Timeless_N.
DR   PANTHER; PTHR22940; PTHR22940; 1.
DR   Pfam; PF04821; TIMELESS; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1054
FT                   /note="Topoisomerase 1-associated factor 1"
FT                   /id="PRO_0000301749"
FT   REGION          522..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          823..846
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          865..953
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          968..1054
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        823..837
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        888..902
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        924..953
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        968..1027
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1054 AA;  120710 MW;  1A239A67C38E6A19 CRC64;
     MEEVDRLVTA SITSIVSALG GCDLASEDAS YVLGEEALAC LKDVKQWLRA FDEKLGRSDV
     AKCIASTTLV VSDIPSILST WNTQSEAGQA SKKMDRVALA CLEILVPLLW PIEINDETPD
     NVVASADLLR QAQIRYKRAL LGHPSKSILK AVVRLCIPSV AKSKADRDQR DIGIMKLVVF
     FIRNMLAIDP MEANGKTDDI NRSAILEAFE NQGVLDLMLT LGSCTGYDIV GVDLPLLDSL
     YQMVKGLDVV EIFETSPNEP DNQLKNLLDT ERRNKPVGSS RHSRFASTMT VLHNGSKISV
     TGPTASIEKS LEKFDKSKQP GRRLTKPTTG VWEVPVFVGH SAKRYIRVFS ELFNDSAFNP
     LMQTVRKALE QEDDIGPAFK HYLVVLKWFL GVEMHRKTPD FGLIASVVNQ EAFIIIMRSI
     RQGVQAKNWT MVKTAMDSFK TTLVVVNLMS DEEVASNIKA RLFYEEEYLT MLADLTRRWA
     LPLTFLQSAV DMTHTLIKTL ESFTKANTTL YVRRRRLRAQ KKADDTGNVE DLESLPGEEH
     ESAIESRERK FNFSSFESRY FHEDTFTTYR MVLSSFQQLD NCYLGWCLKF LDRAFNKRKC
     RVMLFRLDYL QLFRTMVKEL NSSNPWRKPF EHFFKKYMRQ MIPMMKERPC LMVEVIFAKI
     PGTLHYLESG EEKPVRELKE RTSKFVYEFT EGDDIPEERK VCILVASLLD EEKKQLVEWF
     IDELDSLLRA RTGDTQVLNP PKATDELNVP KSIDEDDKFR LLMELVGFTL SRIPKSSVGC
     KTLCSLPGEV SRADIERATG WLKQWYSTPV DFEPFNKIKR VRRDDKERRG AGGDKEGSQD
     AEEDDELPLF LASDSEDDIE NINDEMFAPV PKEKQQKTKQ KLKRKGTSKS TREREKQRDY
     TAKTTIDIPM SYKSADFIGA SDDDSDDERD RKFFEKENEL REELRKAEPT INLEEKVDKA
     FKRQYAYVSD GEEEPLSETE SHKQYREKVD EDRDDLSHMA ERENRQYDFG DEGHDSDNLE
     IIDDDSKSPV AAEGTTSSQP IRKRRIVDDS DDDE
 
 
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