ID   TOFU1_CAEEL             Reviewed;         373 AA.
AC   O17608;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 3.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Protein tofu-1;
DE   AltName: Full=21U-RNA biogenesis fouled up protein 1 {ECO:0000312|WormBase:C27H6.3};
GN   Name=tofu-1 {ECO:0000312|WormBase:C27H6.3};
GN   ORFNames=C27H6.3 {ECO:0000312|WormBase:C27H6.3};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=31216475; DOI=10.1016/j.celrep.2019.05.076;
RA   Zeng C., Weng C., Wang X., Yan Y.H., Li W.J., Xu D., Hong M., Liao S.,
RA   Dong M.Q., Feng X., Xu C., Guang S.;
RT   "Functional Proteomics Identifies a PICS Complex Required for piRNA
RT   Maturation and Chromosome Segregation.";
RL   Cell Rep. 27:3561-3572(2019).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31216475}.
CC   -!- TISSUE SPECIFICITY: Expressed in the germline.
CC       {ECO:0000269|PubMed:31216475}.
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DR   EMBL; BX284605; CAB02794.3; -; Genomic_DNA.
DR   RefSeq; NP_505568.3; NM_073167.6.
DR   AlphaFoldDB; O17608; -.
DR   DIP; DIP-26422N; -.
DR   IntAct; O17608; 3.
DR   STRING; 6239.C27H6.3; -.
DR   PaxDb; O17608; -.
DR   EnsemblMetazoa; C27H6.3.1; C27H6.3.1; WBGene00007785.
DR   GeneID; 179389; -.
DR   KEGG; cel:CELE_C27H6.3; -.
DR   UCSC; C27H6.3; c. elegans.
DR   CTD; 179389; -.
DR   WormBase; C27H6.3; CE41983; WBGene00007785; tofu-1.
DR   eggNOG; ENOG502QVKE; Eukaryota.
DR   HOGENOM; CLU_781285_0_0_1; -.
DR   InParanoid; O17608; -.
DR   OMA; RWIDSCK; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00007785; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..373
FT                   /note="Protein tofu-1"
FT                   /id="PRO_0000452467"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..67
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  41984 MW;  2E2C003672F0FD5B CRC64;
     MAALFEENDS YSDSENEEDF SGFLSEIEEN ENEDEFENDD EFEDDDELEN VDELEDDELS
     SEEVDIPSEN EVIVELHDGQ AEVEESLLDA LLGKALAGDQ MNSRIEGLFE DLDSSVEPDI
     IDRSELEDVD SGISVGAVSS SSAETQASDA KCKNKDAFDM SSLKKYMQYI TEEEHAVSVE
     DIPDFASKKN VYGTSFNVRN GIMSRPPRFE FARHDQRWID SCVSMAYEKD KTLKELITLG
     KLTTTVKAGA KIEFRTKFTD VHIRSADEIN LMETHDIQQI IRDALNSKRL AVVLFGIGKD
     GKVTGCHMGP GQQDNLRLAL DTAVQTEFAP PIENILDVVD MNFVPVEEMD ETFLIVIRVK
     QLRNQVYRLE SSV