TOFU2_CAEEL
ID TOFU2_CAEEL Reviewed; 433 AA.
AC Q19614;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Protein tofu-2;
DE AltName: Full=21U-RNA biogenesis fouled up protein 2 {ECO:0000312|WormBase:F20A1.9};
GN Name=tofu-2 {ECO:0000312|WormBase:F20A1.9};
GN ORFNames=F20A1.9 {ECO:0000312|WormBase:F20A1.9};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=31216475; DOI=10.1016/j.celrep.2019.05.076;
RA Zeng C., Weng C., Wang X., Yan Y.H., Li W.J., Xu D., Hong M., Liao S.,
RA Dong M.Q., Feng X., Xu C., Guang S.;
RT "Functional Proteomics Identifies a PICS Complex Required for piRNA
RT Maturation and Chromosome Segregation.";
RL Cell Rep. 27:3561-3572(2019).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31216475}.
CC -!- TISSUE SPECIFICITY: Expressed in the germline.
CC {ECO:0000269|PubMed:31216475}.
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DR EMBL; BX284605; CCD66547.1; -; Genomic_DNA.
DR PIR; T30040; T30040.
DR RefSeq; NP_504786.2; NM_072385.5.
DR AlphaFoldDB; Q19614; -.
DR SMR; Q19614; -.
DR STRING; 6239.F20A1.9; -.
DR PaxDb; Q19614; -.
DR PeptideAtlas; Q19614; -.
DR EnsemblMetazoa; F20A1.9.1; F20A1.9.1; WBGene00017620.
DR GeneID; 179089; -.
DR KEGG; cel:CELE_F20A1.9; -.
DR UCSC; F20A1.9; c. elegans.
DR CTD; 179089; -.
DR WormBase; F20A1.9; CE35281; WBGene00017620; tofu-2.
DR eggNOG; KOG0349; Eukaryota.
DR GeneTree; ENSGT00940000167826; -.
DR HOGENOM; CLU_633455_0_0_1; -.
DR InParanoid; Q19614; -.
DR OrthoDB; 1274247at2759; -.
DR PhylomeDB; Q19614; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00017620; Expressed in germ line (C elegans) and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.950.30; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007421; Schlafen_AlbA_2_dom.
DR InterPro; IPR038461; Schlafen_AlbA_2_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF04326; AlbA_2; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..433
FT /note="Protein tofu-2"
FT /id="PRO_0000452468"
FT DOMAIN 1..168
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ SEQUENCE 433 AA; 48971 MW; 5BEB803006FE72AC CRC64;
MADTSPRESK LNKQDQDLHL EIDETGLACK SEVKKRWLGA RGTAGLYGNG KYYYEVTITS
KGLCRVGWAT LGGSLNIGKG LDSFGYGGTG MKSTHKKFDD YGLPFTLNDV IGCYLDLDSR
TIWWSKNGEQ FPAAFSIDVK YKNSNTCLFP AVLCQNSSLS VNFGSQPFKF PPGNQFTAVS
DAPNENVNWW SYEEQNSFEH VVVKLPFAVE EDVHNEFRMH TKLMLTELKR TQCKQDKDGS
IRRTLQPISK TICAFLNTDG GRLFLGVNDD KVIKGISMSK NMIYHFFGSL RHMCENFKPC
SPLCRIKVSI LEVIPVGVIK VKLRKADLLK EEAHDFPKLA CHSVGGSFCD CFLEINKAPT
KQYLLIIQVS PPNPNSRTTI FQNEEGLVYR RRMASNKCVY LDDLRRMMNE KNQVFVDLPD
EARAEIDSFS KFD
