ID   TOFU6_CAEBR             Reviewed;         365 AA.
AC   Q621Q3; A8WUF3;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Embryonic developmental protein tofu-6 {ECO:0000305};
DE   AltName: Full=21U-RNA biogenesis fouled up protein 6 {ECO:0000312|WormBase:CBG02394};
DE   AltName: Full=Maternal effect lethal protein 47 {ECO:0000305};
GN   Name=tofu-6 {ECO:0000312|WormBase:CBG02394};
GN   Synonyms=mel-47 {ECO:0000312|WormBase:CBG02394};
GN   ORFNames=CBG02394 {ECO:0000312|WormBase:CBG02394};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Required maternally for early embryonic cell divisions. May
CC       have a role in DNA replication. {ECO:0000250|UniProtKB:Q09293}.
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DR   EMBL; HE601438; CAP24115.3; -; Genomic_DNA.
DR   RefSeq; XP_002630711.1; XM_002630665.1.
DR   AlphaFoldDB; Q621Q3; -.
DR   SMR; Q621Q3; -.
DR   STRING; 6238.CBG02394; -.
DR   PRIDE; Q621Q3; -.
DR   EnsemblMetazoa; CBG02394.1; CBG02394.1; WBGene00025454.
DR   GeneID; 8572227; -.
DR   KEGG; cbr:CBG_02394; -.
DR   CTD; 8572227; -.
DR   WormBase; CBG02394; CBP14399; WBGene00025454; Cbr-tofu-6.
DR   eggNOG; ENOG502SX3Q; Eukaryota.
DR   HOGENOM; CLU_754855_0_0_1; -.
DR   InParanoid; Q621Q3; -.
DR   OMA; NDWNLFH; -.
DR   OrthoDB; 915062at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblMetazoa.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:EnsemblMetazoa.
DR   GO; GO:0034518; C:RNA cap binding complex; IEA:EnsemblMetazoa.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; ISS:UniProtKB.
DR   GO; GO:0006260; P:DNA replication; ISS:UniProtKB.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR   GO; GO:0040016; P:embryonic cleavage; IEA:EnsemblMetazoa.
DR   GO; GO:0051306; P:mitotic sister chromatid separation; IEA:EnsemblMetazoa.
DR   GO; GO:1990511; P:piRNA biosynthetic process; IEA:EnsemblMetazoa.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:EnsemblMetazoa.
DR   GO; GO:0051984; P:positive regulation of chromosome segregation; IEA:EnsemblMetazoa.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Developmental protein; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..365
FT                   /note="Embryonic developmental protein tofu-6"
FT                   /id="PRO_0000298662"
FT   DOMAIN          13..90
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   365 AA;  40797 MW;  40F502E3C15B5BDD CRC64;
     MASSSTAFYL KDAGFHIRNV PKEWNDWNLF HIFQVFGRVG YCRVAGQSND MQLGFVNMLS
     AADAEEVRKN LHDGNLIGDN YSLKVSDHKN IGGALLPMAS ISVQKLLSSP PAKSGPVHLS
     SSWLPLNKDI EVEVVDYLPS SSAAKDVFAL TILRINDAQS NEKYNAMHEK MNSYAQLVAF
     DSELQIGYDG VFRESPRSIK RVRRISATKL YLVDFGKIIN YEKSKCFQIP KVFQTIPTRV
     SFCGLDGLTW SEQAIPSFDN IREVVQKWGA MENATLHAVT CGFAGAINMI NLFCGNSVLA
     ERLQRKGICE YLPRHQQPRF AYSRDSLLKH TNAGVTAHIS NDADVVKDLL KKIDGVKSML
     RELDL