ID   AC78_NPVAC              Reviewed;         109 AA.
AC   Q06693;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Protein AC78;
GN   Name=AC78; ORFNames=ORF78;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E2;
RX   PubMed=8126447; DOI=10.1099/0022-1317-75-3-487;
RA   Kool M., Broer R., Zuidema D., Goldbach R.W., Vlak J.M.;
RT   "Nucleotide sequence and genetic organization of a 7.3 kb region (map unit
RT   47 to 52.5) of Autographa californica nuclear polyhedrosis virus fragment
RT   EcoRI-C.";
RL   J. Gen. Virol. 75:487-494(1994).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=23698311; DOI=10.1128/jvi.01290-13;
RA   Tao X.Y., Choi J.Y., Kim W.J., Lee J.H., Liu Q., Kim S.E., An S.B.,
RA   Lee S.H., Woo S.D., Jin B.R., Je Y.H.;
RT   "The Autographa californica multiple nucleopolyhedrovirus ORF78 is
RT   essential for budded virus production and general occlusion body
RT   formation.";
RL   J. Virol. 87:8441-8450(2013).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=25087880; DOI=10.1016/j.virusres.2014.07.019;
RA   Li S.N., Wang J.Y., Yuan M.J., Yang K.;
RT   "Disruption of the baculovirus core gene ac78 results in decreased
RT   production of multiple nucleocapsid-enveloped occlusion-derived virions and
RT   the failure of primary infection in vivo.";
RL   Virus Res. 191:70-82(2014).
CC   -!- FUNCTION: Plays an essential role in budded virus production and
CC       occlusion body formation. {ECO:0000269|PubMed:23698311,
CC       ECO:0000269|PubMed:25087880}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}. Virion {ECO:0000269|PubMed:23698311}.
CC       Note=Envelope structural protein associated with both budded viruses
CC       (BV) and occlusion-derived viruses (ODV).
CC       {ECO:0000269|PubMed:23698311}.
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DR   EMBL; L22858; AAA66708.1; -; Genomic_DNA.
DR   EMBL; X71415; CAA50541.1; -; Genomic_DNA.
DR   PIR; G72859; G72859.
DR   PIR; S36693; S36693.
DR   RefSeq; NP_054108.1; NC_001623.1.
DR   SMR; Q06693; -.
DR   GeneID; 1403911; -.
DR   KEGG; vg:1403911; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009261; AcMNPV_AC78.
DR   Pfam; PF06024; Orf78; 1.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..109
FT                   /note="Protein AC78"
FT                   /id="PRO_0000133020"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        49
FT                   /note="V -> G (in Ref. 2; CAA50541)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   109 AA;  12545 MW;  B4F55D0EA4CCB5F9 CRC64;
     MNLDVPYYRL GNHEKVEYIP LKLALNDDTA SEPQQFSEPV HKMPINDMVG YDNTTSNVSA
     GIIILISVVA FIALFLLLYV IYYFVILREQ QQYSDSIDTD SPFVFNKFD