ID   TOG2A_AGEAP             Reviewed;          28 AA.
AC   P15971;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Omega-agatoxin-Aa2a;
DE            Short=Omega-AGTX-Aa2a;
DE   AltName: Full=Omega-agatoxin IIA;
DE            Short=Omega-Aga-IIA;
DE   AltName: Full=Omega-agatoxin-2A;
DE   Flags: Fragment;
OS   Agelenopsis aperta (North American funnel-web spider) (Agelenopsis
OS   gertschi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Agelenidae; Agelenopsis.
OX   NCBI_TaxID=6908;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=2295621; DOI=10.1016/s0021-9258(19)40129-4;
RA   Adams M.E., Bindokas V.P., Hasegawa L., Venema V.J.;
RT   "Omega-agatoxins: novel calcium channel antagonists of two subtypes from
RT   funnel web spider (Agelenopsis aperta) venom.";
RL   J. Biol. Chem. 265:861-867(1990).
CC   -!- FUNCTION: Omega-agatoxin are antagonist of voltage-gated calcium
CC       channels. They block insect neuromuscular transmission presynaptically.
CC       Potent blocker of N-type calcium channels (Cav2.2/CACNA1B).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the neurotoxin 04 (omega-agtx) family. 03 (type
CC       II/III omega-agtx) subfamily. {ECO:0000305}.
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DR   PIR; C34923; C34923.
DR   AlphaFoldDB; P15971; -.
DR   ArachnoServer; AS000177; omega-agatoxin-Aa2a (N-terminal fragment).
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR005853; Omega-agatoxin_II/III_CS.
DR   InterPro; IPR013605; Toxin_34.
DR   Pfam; PF08396; Toxin_34; 1.
DR   PROSITE; PS60023; OMEGA_AGA_II_III; 1.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing;
KW   Ion channel impairing toxin; Neurotoxin; Presynaptic neurotoxin; Secreted;
KW   Toxin; Voltage-gated calcium channel impairing toxin.
FT   CHAIN           1..>28
FT                   /note="Omega-agatoxin-Aa2a"
FT                   /id="PRO_0000087605"
FT   NON_TER         28
SQ   SEQUENCE   28 AA;  3053 MW;  0EDD253248A6C9AE CRC64;
     GCIEIGGDCD GYQEKSYCQC CRNNGFCS