ID   TOG3D_AGEAP             Reviewed;          37 AA.
AC   P81746;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2001, sequence version 1.
DT   23-FEB-2022, entry version 58.
DE   RecName: Full=Omega-agatoxin-Aa3d;
DE            Short=Omega-AGTX-Aa3d;
DE   AltName: Full=Omega-agatoxin IIID;
DE            Short=Omega-Aga-IIID;
DE   AltName: Full=Omega-agatoxin-3D;
DE   Flags: Fragment;
OS   Agelenopsis aperta (North American funnel-web spider) (Agelenopsis
OS   gertschi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Agelenidae; Agelenopsis.
OX   NCBI_TaxID=6908;
RN   [1]
RP   PROTEIN SEQUENCE, AND CHARACTERIZATION.
RC   TISSUE=Venom;
RX   PubMed=8172884; DOI=10.1021/bi00183a013;
RA   Ertel E.A., Warren V.A., Adams M.E., Griffin P.R., Cohen C.J., Smith M.M.;
RT   "Type III omega-agatoxins: a family of probes for similar binding sites on
RT   L- and N-type calcium channels.";
RL   Biochemistry 33:5098-5108(1994).
CC   -!- FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium
CC       channels. This toxin blocks calcium channels in insect central neurons
CC       but not at peripheral neuromuscular junctions. In vertebrates, it is
CC       broadly active against all high-threshold Cav1/CACNA1 channels and
CC       Cav2.2/CACNA1B channels.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Disulfide bonds are present. {ECO:0000305}.
CC   -!- MISCELLANEOUS: This toxin does not inhibit Cav3 (T-type) channels.
CC   -!- SIMILARITY: Belongs to the neurotoxin 04 (omega-agtx) family. 03 (type
CC       II/III omega-agtx) subfamily. {ECO:0000305}.
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DR   PIR; F54252; F54252.
DR   ArachnoServer; AS000181; omega-agatoxin-Aa3d (N-terminal fragment).
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR005853; Omega-agatoxin_II/III_CS.
DR   InterPro; IPR013605; Toxin_34.
DR   Pfam; PF08396; Toxin_34; 1.
DR   PROSITE; PS60023; OMEGA_AGA_II_III; 1.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   CHAIN           1..>37
FT                   /note="Omega-agatoxin-Aa3d"
FT                   /id="PRO_0000087609"
FT   NON_TER         37
SQ   SEQUENCE   37 AA;  4084 MW;  89E46267B3846D93 CRC64;
     SCIKIGEDCD GDKDDCQCCR TNGYCSXYXL FGYLKSG