TOIP1_BOVIN
ID TOIP1_BOVIN Reviewed; 600 AA.
AC F1N4E5;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 2.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Torsin-1A-interacting protein 1;
DE AltName: Full=Lamin-associated protein 1B;
DE Short=LAP1B;
GN Name=TOR1AIP1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
CC -!- FUNCTION: Required for nuclear membrane integrity. Induces TOR1A and
CC TOR1B ATPase activity and is required for their location on the nuclear
CC membrane. Binds to A- and B-type lamins. Possible role in membrane
CC attachment and assembly of the nuclear lamina (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ATP1B4. Interacts with TOR1A (ATP-bound).
CC Interacts with TOR1B, TOR2A and TOR3A. Interacts with VIM (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TOR1AIP family. {ECO:0000305}.
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DR EMBL; DAAA02043477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F1N4E5; -.
DR SMR; F1N4E5; -.
DR STRING; 9913.ENSBTAP00000033870; -.
DR PaxDb; F1N4E5; -.
DR PRIDE; F1N4E5; -.
DR Ensembl; ENSBTAT00000033967; ENSBTAP00000033870; ENSBTAG00000035226.
DR VEuPathDB; HostDB:ENSBTAG00000035226; -.
DR VGNC; VGNC:36224; TOR1AIP1.
DR eggNOG; ENOG502QUV7; Eukaryota.
DR GeneTree; ENSGT00390000012166; -.
DR HOGENOM; CLU_034263_0_1_1; -.
DR InParanoid; F1N4E5; -.
DR TreeFam; TF329438; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000035226; Expressed in spermatid and 104 other tissues.
DR ExpressionAtlas; F1N4E5; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001671; F:ATPase activator activity; ISS:UniProtKB.
DR GO; GO:0061024; P:membrane organization; IBA:GO_Central.
DR GO; GO:0071763; P:nuclear membrane organization; IBA:GO_Central.
DR GO; GO:0032781; P:positive regulation of ATP-dependent activity; ISS:UniProtKB.
DR GO; GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
DR Gene3D; 3.40.50.12190; -; 1.
DR InterPro; IPR038599; LAP1C-like_C_sf.
DR InterPro; IPR008662; TOIP1/2.
DR PANTHER; PTHR18843; PTHR18843; 1.
DR Pfam; PF05609; LAP1C; 1.
PE 3: Inferred from homology;
KW Coiled coil; Glycoprotein; Isopeptide bond; Membrane; Nucleus;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Ubl conjugation.
FT CHAIN 1..600
FT /note="Torsin-1A-interacting protein 1"
FT /id="PRO_0000417025"
FT TOPO_DOM 1..354
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..600
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT REGION 1..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..600
FT /note="Interaction with TOR1A"
FT /evidence="ECO:0000250"
FT COILED 376..452
FT /evidence="ECO:0000255"
FT COMPBIAS 52..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 61
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q921T2"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT MOD_RES 145
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT MOD_RES 156
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT MOD_RES 158
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT MOD_RES 189
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT MOD_RES 223
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT MOD_RES 230
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT MOD_RES 233
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5PQX1"
FT MOD_RES 244
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5PQX1"
FT MOD_RES 322
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT MOD_RES 332
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
FT CARBOHYD 416
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CROSSLNK 325
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5JTV8"
SQ SEQUENCE 600 AA; 67468 MW; 0BDC048C3B12CD28 CRC64;
MAGEGQRAEP EREGWALYVT PRAPLREGRP RLAPQNGGSG DVPAYGTPTP SRHGRREVRF
SEEPPEVYGD FEPRAAKEKA RVGRQIPLEG FRPDSAKEEV RESAYYLRSR QRRQPRLHEA
EEMQTRRAAL LQQQPHSPPP PLRPSPVTTR RGLRDSHSSE EDEPPSQTVL SQTVTKKAIR
RTQETPVMSE DPLISLRRPP LRSSRSEAAS VQQKVNFLEE GETEENDQDS FDSDVTVKVR
SGDSVESGDQ TTRSSSQYKE SFWQSSQSGD FTAFDEQPLK LSSGYQKTPQ EWAEKTVRIR
TRMLTSSPGM RSIYGSFSDD DSVQKSELGN QSPSTSNQQM TGQPKSVSSV KTKRYWPFAV
IAALLIGGFL YTRPPEAETT AVQEFQNQMK QLMNKYQGQD EKLWKRSQTF LEKHLNGSQS
RPQPAILLLT AARDAEEALR CLSEQIADAY SSFRSVPAIR IDGASKATRD SDTVKEEVDQ
ELSNGFRNGQ NAAVVHRFES LPAGSTLIFY KYCDHESAAF KDVALVLTVL LEEETLGTSL
GLKEIEEKVR DFLQVKFTNS DTPNSYKHMD PDKLSGLWSR ISHLVLPVQP ENDLKKGICL
