ID   TOIPA_XENLA             Reviewed;         269 AA.
AC   Q3B8H2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Toll-interacting protein A;
GN   Name=tollip-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the signaling pathway of IL-1 and Toll-like
CC       receptors. Inhibits cell activation by microbial products. Connects the
CC       ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8
CC       family adapter and thus mediating autophagic clearance of ubiquitin
CC       conjugates. The TOLLIP-dependent selective autophagy pathway plays an
CC       important role in clearance of cytotoxic polyQ proteins aggregates (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ATG8 family proteins (via AIM motifs), and
CC       ubiquitin (via CUE domain). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DOMAIN: Both ATG8-interaction motifs (AIM1 and AIM2) are required for
CC       the association with ATG8 family proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tollip family. {ECO:0000305}.
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DR   EMBL; BC106437; AAI06438.1; -; mRNA.
DR   RefSeq; NP_001089737.1; NM_001096268.1.
DR   AlphaFoldDB; Q3B8H2; -.
DR   SMR; Q3B8H2; -.
DR   MaxQB; Q3B8H2; -.
DR   DNASU; 734800; -.
DR   GeneID; 734800; -.
DR   KEGG; xla:734800; -.
DR   CTD; 734800; -.
DR   Xenbase; XB-GENE-6255027; tollip.S.
DR   OMA; IYIQIFD; -.
DR   OrthoDB; 1219350at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 734800; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; ISS:UniProtKB.
DR   CDD; cd04016; C2_Tollip; 1.
DR   CDD; cd14363; CUE_TOLIP; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR003892; CUE.
DR   InterPro; IPR041799; TOLIP_CUE.
DR   InterPro; IPR037301; Tollip_C2.
DR   InterPro; IPR009060; UBA-like_sf.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF02845; CUE; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00546; CUE; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS51140; CUE; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Immunity; Inflammatory response; Innate immunity;
KW   Reference proteome; Repeat.
FT   CHAIN           1..269
FT                   /note="Toll-interacting protein A"
FT                   /id="PRO_0000384938"
FT   DOMAIN          35..152
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          224..267
FT                   /note="CUE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT   MOTIF           133..136
FT                   /note="AIM1"
FT   MOTIF           151..154
FT                   /note="AIM2"
SQ   SEQUENCE   269 AA;  29878 MW;  D8D28CDD09623BF7 CRC64;
     MATSISTQRG QVFIGELPQD FLRIAPTQQQ QQIQLDAQAA QQLQYSGVMG TMGRLSITVV
     QAKLAKNYGM TRMDPYCRIR LGYAVYETPT AHNGAKNPRW NKVIQCTIPP GVDSFYLEIF
     DERAFSMDDR IAWTHITIPE TLKEGKHVDE WFSLSGRQGD DKEGMINLVM SYTSVPAMMP
     AQPVVLMPTV YQQGVGYVPI AGPVYNPGMP MIASPPAVNP QHQTQEVDIQ SIKDMFPTID
     PEVIRSVLEA QGGNRDAAIN SLLQMVEDS