ID   TOK1H_HADVE             Reviewed;          76 AA.
AC   S0F209;
DT   29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Omega/Kappa-hexatoxin-Hv1h {ECO:0000303|PubMed:24593665};
DE   Flags: Precursor;
OS   Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Hexathelidae; Hadronyche.
OX   NCBI_TaxID=6904;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24593665; DOI=10.1186/1471-2164-15-177;
RA   Pineda S.S., Sollod B.L., Wilson D., Darling A., Sunagar K., Undheim E.A.,
RA   Kely L., Antunes A., Fry B.G., King G.F.;
RT   "Diversification of a single ancestral gene into a successful toxin
RT   superfamily in highly venomous Australian funnel-web spiders.";
RL   BMC Genomics 15:177-177(2014).
CC   -!- FUNCTION: Toxin that may inhibit ion channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24593665}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24593665}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurotoxin 08 (Shiva) family. 02
CC       (omega/kappa toxin) subfamily. {ECO:0000305}.
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DR   EMBL; HG001308; CDF44169.1; -; mRNA.
DR   AlphaFoldDB; S0F209; -.
DR   BMRB; S0F209; -.
DR   SMR; S0F209; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019855; F:calcium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   InterPro; IPR009415; Omega-atracotox.
DR   Pfam; PF06357; Omega-toxin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..35
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000430900"
FT   CHAIN           38..76
FT                   /note="Omega/Kappa-hexatoxin-Hv1h"
FT                   /id="PRO_0000430901"
FT   DISULFID        40..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   76 AA;  8395 MW;  E56FEFB451476CC5 CRC64;
     MNTATGFIVL LVLATILGGI EAGESHMRKD AMGRVRRQYC VPVDQPCSLN TQPCCDDATC
     TQERNENGHT VYYCRA