TOL7_ARATH
ID TOL7_ARATH Reviewed; 542 AA.
AC F4KAU9; Q8GWW0; Q9LZX0;
DT 05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=TOM1-like protein 7 {ECO:0000305};
GN Name=TOL7 {ECO:0000303|PubMed:24316203};
GN Synonyms=TOM1B {ECO:0000303|PubMed:22639582};
GN OrderedLocusNames=At5g01760 {ECO:0000312|Araport:AT5G01760};
GN ORFNames=T20L15.30 {ECO:0000312|EMBL:CAB82746.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP GENE FAMILY, AND REVIEW.
RX PubMed=16488176; DOI=10.1016/j.tplants.2006.01.008;
RA Winter V., Hauser M.-T.;
RT "Exploring the ESCRTing machinery in eukaryotes.";
RL Trends Plant Sci. 11:115-123(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22639582; DOI=10.3389/fpls.2011.00020;
RA Richardson L.G., Howard A.S., Khuu N., Gidda S.K., McCartney A.,
RA Morphy B.J., Mullen R.T.;
RT "Protein-protein interaction network and subcellular localization of the
RT Arabidopsis thaliana ESCRT machinery.";
RL Front. Plant Sci. 2:20-20(2011).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24316203; DOI=10.1016/j.cub.2013.10.036;
RA Korbei B., Moulinier-Anzola J., De-Araujo L., Lucyshyn D., Retzer K.,
RA Khan M.A., Luschnig C.;
RT "Arabidopsis TOL proteins act as gatekeepers for vacuolar sorting of PIN2
RT plasma membrane protein.";
RL Curr. Biol. 23:2500-2505(2013).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=24699223; DOI=10.4161/psb.28667;
RA Moulinier-Anzola J., De-Araujo L., Korbei B.;
RT "Expression of Arabidopsis TOL genes.";
RL Plant Signal. Behav. 9:E28667-E28667(2014).
CC -!- FUNCTION: Might contribute to the loading of the ESCRT machinery.
CC {ECO:0000305|PubMed:16488176}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in flowers.
CC {ECO:0000269|PubMed:24699223}.
CC -!- SIMILARITY: Belongs to the TOM1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC43199.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC43199.1; Type=Miscellaneous discrepancy; Note=Introns retention.; Evidence={ECO:0000305};
CC Sequence=CAB82746.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL162351; CAB82746.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED90388.1; -; Genomic_DNA.
DR EMBL; AK118600; BAC43199.1; ALT_SEQ; mRNA.
DR PIR; T48197; T48197.
DR RefSeq; NP_195796.2; NM_120254.3.
DR AlphaFoldDB; F4KAU9; -.
DR SMR; F4KAU9; -.
DR STRING; 3702.AT5G01760.1; -.
DR PaxDb; F4KAU9; -.
DR PRIDE; F4KAU9; -.
DR ProteomicsDB; 232461; -.
DR EnsemblPlants; AT5G01760.1; AT5G01760.1; AT5G01760.
DR GeneID; 831682; -.
DR Gramene; AT5G01760.1; AT5G01760.1; AT5G01760.
DR KEGG; ath:AT5G01760; -.
DR Araport; AT5G01760; -.
DR TAIR; locus:2180982; AT5G01760.
DR eggNOG; KOG1087; Eukaryota.
DR HOGENOM; CLU_026748_2_1_1; -.
DR InParanoid; F4KAU9; -.
DR OMA; WQCKDAI; -.
DR OrthoDB; 521769at2759; -.
DR PRO; PR:F4KAU9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4KAU9; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:InterPro.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR044836; TOL_plant.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45898; PTHR45898; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; SSF48464; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport.
FT CHAIN 1..542
FT /note="TOM1-like protein 7"
FT /id="PRO_0000440682"
FT DOMAIN 29..158
FT /note="VHS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00218"
FT DOMAIN 201..289
FT /note="GAT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00373"
FT REGION 303..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 161
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O80910"
FT MOD_RES 521
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O80910"
SQ SEQUENCE 542 AA; 59768 MW; C3E8B2C4433A9986 CRC64;
MRPSCASSSS SSASPSLRLS SVTVAVDKAT SELLRTPDWT IIIAICDSLN SNRWQCKDAI
KAVKRRLQHK SSRVQLLTLT LLEAMLKNCG DFVHSHIAEK HLLEDMVKLV RKKGDFEVRN
KLLILLDTWN EAFSGVACKH PHYNWAYQEL KRCGVKFPQR SKEAPLMLEP PPPVTQSSSS
SSMNLMSIGS FRRLDETMAT EIESLSLSSL ESMRNVMDLV NDMVQAVNPS DKSALKDELI
VDLVEQCRSN QKKLIQMLTT TADEDVLARG LELNDSLQVV LARHDAIASG VSLPLLLQAP
EPRETSSSLK TCGAAALESA DSESSSSSSS SESETDEVED VKDDFIQLAK RHALLNALHS
DEEEETLLLG NDNEKTAEAE AKTQCKDLAL FDTTTTTTTK SEQDIIELLS LTLSTTALPS
PQTQPQTQHP SFFADDNILM NSYVVPWAQS QEEPQVPKMT QFAPSGPQFQ PWPLQQQQPY
SYGYPQPQWS GGQVNSNDTT FWSQGGNENM VFERNLQVSN SFPARATGTS GAATAATVDR
QP
