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TOLA_HAEIN
ID   TOLA_HAEIN              Reviewed;         372 AA.
AC   P44678; P94810;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Tol-Pal system protein TolA {ECO:0000305};
GN   Name=tolA; OrderedLocusNames=HI_0383;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1479;
RX   PubMed=8921895; DOI=10.1016/0378-1119(96)00338-1;
RA   Sen K., Sikkema D.J., Murphy T.F.;
RT   "Isolation and characterization of the Haemophilus influenzae tolQ, tolR,
RT   tolA and tolB genes.";
RL   Gene 178:75-81(1996).
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. {ECO:0000250|UniProtKB:P19934}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000250|UniProtKB:P19934}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P19934}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:P19934}.
CC   -!- SIMILARITY: Belongs to the TolA family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22041.1; -; Genomic_DNA.
DR   EMBL; U32470; AAC44596.1; -; Genomic_DNA.
DR   PIR; G64064; G64064.
DR   RefSeq; NP_438544.1; NC_000907.1.
DR   RefSeq; WP_005693785.1; NC_000907.1.
DR   AlphaFoldDB; P44678; -.
DR   SMR; P44678; -.
DR   STRING; 71421.HI_0383; -.
DR   PRIDE; P44678; -.
DR   EnsemblBacteria; AAC22041; AAC22041; HI_0383.
DR   KEGG; hin:HI_0383; -.
DR   PATRIC; fig|71421.8.peg.401; -.
DR   eggNOG; COG3064; Bacteria.
DR   HOGENOM; CLU_035992_0_0_6; -.
DR   OMA; FNLFRDI; -.
DR   BioCyc; HINF71421:G1GJ1-398-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0043213; P:bacteriocin transport; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR014161; Tol-Pal_TolA.
DR   Pfam; PF06519; TolA; 1.
DR   TIGRFAMs; TIGR02794; tolA_full; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..372
FT                   /note="Tol-Pal system protein TolA"
FT                   /id="PRO_0000072623"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P19934"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..372
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:P19934"
FT   REGION          64..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..139
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         48
FT                   /note="V -> A (in strain: 1479)"
FT   VARIANT         142
FT                   /note="K -> R (in strain: 1479)"
FT   VARIANT         165
FT                   /note="A -> P (in strain: 1479)"
FT   VARIANT         190
FT                   /note="A -> R (in strain: 1479)"
FT   VARIANT         203
FT                   /note="V -> A (in strain: 1479)"
FT   VARIANT         227
FT                   /note="D -> A (in strain: 1479)"
FT   VARIANT         232
FT                   /note="A -> AKAAAEAKAKA (in strain: 1479)"
FT   VARIANT         234
FT                   /note="T -> A (in strain: 1479)"
FT   VARIANT         249
FT                   /note="L -> F (in strain: 1479)"
FT   VARIANT         254
FT                   /note="I -> V (in strain: 1479)"
FT   VARIANT         306
FT                   /note="N -> S (in strain: 1479)"
FT   VARIANT         323
FT                   /note="T -> A (in strain: 1479)"
FT   VARIANT         333
FT                   /note="S -> P (in strain: 1479)"
SQ   SEQUENCE   372 AA;  39831 MW;  266ECF05C6C95544 CRC64;
     MQNNRQKKGI NAFAISILLH FILFGLLILS SLYHTVEIMG GGEGEGDVIG AVIVDTGTAA
     QEWGRIQQQK KGQADKQKRP EPVVEEKPPE PNQEEIKHQQ EVQRQEELKR QQEQQRQQEI
     KKQQEQARQE ALEKQKQAEE AKAKQAAEAA KLKADAEAKR LAAAAKQAEE EAKAKAAEIA
     AQKAKQEAEA KAKLEAEAKA KAVAEAKAKA EAEAKAKAAA EAKAKADAEA KAATEAKRKA
     DQASLDDFLN GGDIGGGSAS KGGNTNKGGT QGSGAALGSG DGGKVGDQYA GVIKKEIQRR
     FLKDPNFAGK VCRIKIQLGR DGTILGYQKI SGSDDICSAA LSAVARTKKV PAAPSDEIYE
     KYKSPIIDFD IR
 
 
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