TOLA_HAEIN
ID TOLA_HAEIN Reviewed; 372 AA.
AC P44678; P94810;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Tol-Pal system protein TolA {ECO:0000305};
GN Name=tolA; OrderedLocusNames=HI_0383;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=1479;
RX PubMed=8921895; DOI=10.1016/0378-1119(96)00338-1;
RA Sen K., Sikkema D.J., Murphy T.F.;
RT "Isolation and characterization of the Haemophilus influenzae tolQ, tolR,
RT tolA and tolB genes.";
RL Gene 178:75-81(1996).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. {ECO:0000250|UniProtKB:P19934}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000250|UniProtKB:P19934}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P19934}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P19934}.
CC -!- SIMILARITY: Belongs to the TolA family. {ECO:0000305}.
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DR EMBL; L42023; AAC22041.1; -; Genomic_DNA.
DR EMBL; U32470; AAC44596.1; -; Genomic_DNA.
DR PIR; G64064; G64064.
DR RefSeq; NP_438544.1; NC_000907.1.
DR RefSeq; WP_005693785.1; NC_000907.1.
DR AlphaFoldDB; P44678; -.
DR SMR; P44678; -.
DR STRING; 71421.HI_0383; -.
DR PRIDE; P44678; -.
DR EnsemblBacteria; AAC22041; AAC22041; HI_0383.
DR KEGG; hin:HI_0383; -.
DR PATRIC; fig|71421.8.peg.401; -.
DR eggNOG; COG3064; Bacteria.
DR HOGENOM; CLU_035992_0_0_6; -.
DR OMA; FNLFRDI; -.
DR BioCyc; HINF71421:G1GJ1-398-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0043213; P:bacteriocin transport; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR InterPro; IPR014161; Tol-Pal_TolA.
DR Pfam; PF06519; TolA; 1.
DR TIGRFAMs; TIGR02794; tolA_full; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..372
FT /note="Tol-Pal system protein TolA"
FT /id="PRO_0000072623"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P19934"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..372
FT /note="Periplasmic"
FT /evidence="ECO:0000250|UniProtKB:P19934"
FT REGION 64..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 48
FT /note="V -> A (in strain: 1479)"
FT VARIANT 142
FT /note="K -> R (in strain: 1479)"
FT VARIANT 165
FT /note="A -> P (in strain: 1479)"
FT VARIANT 190
FT /note="A -> R (in strain: 1479)"
FT VARIANT 203
FT /note="V -> A (in strain: 1479)"
FT VARIANT 227
FT /note="D -> A (in strain: 1479)"
FT VARIANT 232
FT /note="A -> AKAAAEAKAKA (in strain: 1479)"
FT VARIANT 234
FT /note="T -> A (in strain: 1479)"
FT VARIANT 249
FT /note="L -> F (in strain: 1479)"
FT VARIANT 254
FT /note="I -> V (in strain: 1479)"
FT VARIANT 306
FT /note="N -> S (in strain: 1479)"
FT VARIANT 323
FT /note="T -> A (in strain: 1479)"
FT VARIANT 333
FT /note="S -> P (in strain: 1479)"
SQ SEQUENCE 372 AA; 39831 MW; 266ECF05C6C95544 CRC64;
MQNNRQKKGI NAFAISILLH FILFGLLILS SLYHTVEIMG GGEGEGDVIG AVIVDTGTAA
QEWGRIQQQK KGQADKQKRP EPVVEEKPPE PNQEEIKHQQ EVQRQEELKR QQEQQRQQEI
KKQQEQARQE ALEKQKQAEE AKAKQAAEAA KLKADAEAKR LAAAAKQAEE EAKAKAAEIA
AQKAKQEAEA KAKLEAEAKA KAVAEAKAKA EAEAKAKAAA EAKAKADAEA KAATEAKRKA
DQASLDDFLN GGDIGGGSAS KGGNTNKGGT QGSGAALGSG DGGKVGDQYA GVIKKEIQRR
FLKDPNFAGK VCRIKIQLGR DGTILGYQKI SGSDDICSAA LSAVARTKKV PAAPSDEIYE
KYKSPIIDFD IR