ID   TOLB_BRUME              Reviewed;         443 AA.
AC   Q93TG4;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE   Flags: Precursor;
GN   Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=BMEI0339;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RA   Tibor A., Aidant N., Letesson J.-J.;
RT   "The tol-pal region in Brucella encodes homologs of the Tol-Pal system of
RT   E. coli.";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
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DR   EMBL; AF358662; AAK48918.1; -; Genomic_DNA.
DR   EMBL; AE008917; AAL51520.1; -; Genomic_DNA.
DR   PIR; AE3294; AE3294.
DR   RefSeq; WP_004684149.1; NZ_GG703781.1.
DR   AlphaFoldDB; Q93TG4; -.
DR   SMR; Q93TG4; -.
DR   STRING; 224914.BMEI0339; -.
DR   EnsemblBacteria; AAL51520; AAL51520; BMEI0339.
DR   GeneID; 29593087; -.
DR   KEGG; bme:BMEI0339; -.
DR   PATRIC; fig|224914.52.peg.1153; -.
DR   eggNOG; COG0823; Bacteria.
DR   OMA; VREPSWG; -.
DR   PhylomeDB; Q93TG4; -.
DR   Proteomes; UP000000419; Chromosome I.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0017038; P:protein import; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 1.
DR   HAMAP; MF_00671; TolB; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR014167; Tol-Pal_TolB.
DR   InterPro; IPR007195; TolB_N.
DR   Pfam; PF07676; PD40; 3.
DR   Pfam; PF04052; TolB_N; 1.
DR   TIGRFAMs; TIGR02800; propeller_TolB; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Periplasm; Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT   CHAIN           34..443
FT                   /note="Tol-Pal system protein TolB"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT                   /id="PRO_0000034630"
SQ   SEQUENCE   443 AA;  48501 MW;  327A09043D974762 CRC64;
     MKIGIINTKI RTVFSAFACM IAASLVCTMP ARAVVEININ KGVIEPLPIA ITDFLSADQL
     GSNITSVIAA DLERSGLFAP IDTGAFIEKI SNPDAAPRFE DWKVINAQAL VTGRITKQPD
     GRLKAEFRLW DTFGGQQMIG QQFFTTPDNW RRVAHIIADA IYERLTGDKG YFDTRVVFVD
     ESGPAQKRVK RLAIMDQDGA NVRFISDGRA LSLTPRFSPN RQEVTYMSFE GGSPKVYLLQ
     LETGQRELVG NFPGMTIAPR FSPDGQKVVM SLLQDDGSAN IYTMDLRNRT TTRLTSSQAI
     DTGASYSPDG SQIVFTSDRG GRPQLYVMGA DGSNPRRISM GDGSYSTPVW SPRGDLIAFT
     KQSQGQFSIG VMKTDGSGER LLTSGFHNEG PTWAPNGRVL MFFRKAAGAG GPKLFTIDLT
     GRNERQIQTP NFASDPAWSP LLE