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TOLB_COXBU
ID   TOLB_COXBU              Reviewed;         437 AA.
AC   Q83F59;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE   Flags: Precursor;
GN   Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=CBU_0090;
OS   Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC   Coxiella.
OX   NCBI_TaxID=227377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSA 493 / Nine Mile phase I;
RX   PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA   Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA   Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA   Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA   Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA   Fraser C.M., Heidelberg J.F.;
RT   "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Nine Mile Crazy / RSA 514;
RX   PubMed=17088354; DOI=10.1128/iai.00883-06;
RA   Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J.,
RA   Samuel J.E., Heinzen R.A.;
RT   "Proteome and antigen profiling of Coxiella burnetii developmental forms.";
RL   Infect. Immun. 75:290-298(2007).
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- DEVELOPMENTAL STAGE: More than twofold more abundant in the small cell
CC       variant (SCV) stage than in the large cell variant (LCV) stage (at
CC       protein level). LCVs are more metabolically active than SCVs.
CC       {ECO:0000269|PubMed:17088354}.
CC   -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO89656.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016828; AAO89656.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_819142.2; NC_002971.3.
DR   AlphaFoldDB; Q83F59; -.
DR   SMR; Q83F59; -.
DR   STRING; 227377.CBU_0090; -.
DR   EnsemblBacteria; AAO89656; AAO89656; CBU_0090.
DR   GeneID; 1207960; -.
DR   KEGG; cbu:CBU_0090; -.
DR   PATRIC; fig|227377.7.peg.91; -.
DR   eggNOG; COG0823; Bacteria.
DR   HOGENOM; CLU_047123_0_0_6; -.
DR   OMA; VREPSWG; -.
DR   Proteomes; UP000002671; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0017038; P:protein import; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 1.
DR   HAMAP; MF_00671; TolB; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR014167; Tol-Pal_TolB.
DR   InterPro; IPR007195; TolB_N.
DR   Pfam; PF07676; PD40; 4.
DR   Pfam; PF04052; TolB_N; 1.
DR   TIGRFAMs; TIGR02800; propeller_TolB; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT   CHAIN           24..437
FT                   /note="Tol-Pal system protein TolB"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT                   /id="PRO_0000034644"
SQ   SEQUENCE   437 AA;  47792 MW;  587C4231E41133D0 CRC64;
     MQKRHPIIYL LITLLIFVPV SYGALDLELT KGVTAAIPIA IMPFAGPSVL APGDETIPQV
     IKNDLQNSGQ FRVTGSGNLD QTAASLEQID YSYWRKQKVN ALVVGAINPL GMRRYRVAFT
     LINVFDSNNR LLSESFNVNA KELRNLAHHI SDLIYQKLTG VRGVFSTKIA YVLVQASSEN
     TAAKYTLEVA DADGFNPQPL LVSDMPIMSP TWSPDGNKIA YVSFEGHRAA IYLQDLATGR
     RQRLSEAPGI NGAPAFSPDG KQLALVLTKT GNPKIYILNL ADGHLREITK GWSIDTEPAW
     SPDGKSLLFT SNRDGTPQIY NYSFADGSIN RVTYRGDYNA RPSFMPDGKS IIMMHRENGL
     FGIARQDLST GQVQILSESG TDESPSLAPN GKMAIYAMEY GGRGVLAQVS IDGQIKLRLP
     ARNGNVQEPA WSPYLGV
 
 
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