ID   BTN1_ASHGO              Reviewed;         412 AA.
AC   Q758C3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Protein BTN1;
DE   Flags: Precursor;
GN   Name=BTN1; OrderedLocusNames=AEL171C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in vacuolar transport and vacuole pH homeostasis.
CC       Also required for cytokinesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016818; AAS52514.1; -; Genomic_DNA.
DR   RefSeq; NP_984690.1; NM_210043.1.
DR   AlphaFoldDB; Q758C3; -.
DR   STRING; 33169.AAS52514; -.
DR   EnsemblFungi; AAS52514; AAS52514; AGOS_AEL171C.
DR   GeneID; 4620875; -.
DR   KEGG; ago:AGOS_AEL171C; -.
DR   eggNOG; KOG3880; Eukaryota.
DR   HOGENOM; CLU_029663_1_2_1; -.
DR   InParanoid; Q758C3; -.
DR   OMA; WLCNWQV; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0000324; C:fungal-type vacuole; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR   GO; GO:1903826; P:L-arginine transmembrane transport; IEA:EnsemblFungi.
DR   GO; GO:0015819; P:lysine transport; IEA:EnsemblFungi.
DR   GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR   InterPro; IPR003492; Battenin_disease_Cln3.
DR   InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10981; PTHR10981; 1.
DR   Pfam; PF02487; CLN3; 1.
DR   PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR   PRINTS; PR01315; BATTENIN.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..412
FT                   /note="Protein BTN1"
FT                   /id="PRO_0000256255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   412 AA;  45668 MW;  411902126FE3725A CRC64;
     MDRRKLIFGK FWLFGLLNNV LYVVILAAAV DIVGPTLPKS LILLADILPS FLVKLVAPFF
     IDRVEYHYRI WSLIALSGFG MLLVASGRLG VCIVGIVLAS ISSGVGEITF LQLTHYFSHV
     ALNGWSSGTG GAGLAGSFLY MLLTSILKIP VSRSLLLFSI LPIGFLLYFT LQVERTAYEP
     LASGHFMEAE DNSGSVISLE APRTTVDNAR DCASRPRLAA LRERIEVTMR RLKVLVVPYM
     IPLSTVYLFE YLINQGVSPT LMFPIHEGYG TSQLFHKYRD IYVAYGTLYQ LGVFISRSSG
     SWVRIRGLYL LSVLQFLNLV ILLIQSWYYV IHSVWVIMAI VLYEGLLGGA SYVNSFLNIS
     EDVPLAEREF SLGAVSISDS SGTLVAAFIG ILLEPVLCSH QVKTGRPWCQ LE