BTN1_ASPFU
ID BTN1_ASPFU Reviewed; 460 AA.
AC Q4X0S3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Protein btn1;
GN Name=btn1; ORFNames=AFUA_2G12480;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in vacuolar transport and vacuole pH homeostasis.
CC Also required for cytokinesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
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DR EMBL; AAHF01000001; EAL93542.1; -; Genomic_DNA.
DR RefSeq; XP_755580.1; XM_750487.1.
DR AlphaFoldDB; Q4X0S3; -.
DR STRING; 746128.CADAFUBP00002753; -.
DR EnsemblFungi; EAL93542; EAL93542; AFUA_2G12480.
DR GeneID; 3513009; -.
DR KEGG; afm:AFUA_2G12480; -.
DR VEuPathDB; FungiDB:Afu2g12480; -.
DR eggNOG; KOG3880; Eukaryota.
DR HOGENOM; CLU_029663_1_2_1; -.
DR InParanoid; Q4X0S3; -.
DR OMA; WLCNWQV; -.
DR OrthoDB; 1037817at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0000324; C:fungal-type vacuole; IEA:EnsemblFungi.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:1903826; P:L-arginine transmembrane transport; IEA:EnsemblFungi.
DR GO; GO:0015819; P:lysine transport; IEA:EnsemblFungi.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR003492; Battenin_disease_Cln3.
DR InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10981; PTHR10981; 1.
DR Pfam; PF02487; CLN3; 1.
DR PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR PRINTS; PR01315; BATTENIN.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..460
FT /note="Protein btn1"
FT /id="PRO_0000256256"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 460 AA; 50252 MW; 59936C3ECE1F6944 CRC64;
MPAAADTEEE QPMLPLPGAP SSSWAQFCQR FRALFSGADP RVCVAFWLFG LINNVLYVVI
LSAALDLVGP SVPKGVVLLA DVIPSFATKL IAPYFIHMVP YPVRIIIFVF LSAAGMLLVA
LSPPYTDGGT IATKLAGIVL ASLSSGGGEL SFVGLTHFYG PFSLAAWGSG TGAAGLVGAG
AYALATTSLG LSVKATLLAS SCLPAVMVVS FFMVLPRSPL QPISAAYAGY RAVEEREELA
EEREFMEGDR DATFDEQERL LGASVLSDQS KKAGWQRFKR DLKRVRGLFF PFMLPLLLVY
VAEYTINQGV SPTLLFPLDE SPFAHFRAFY PAYNAIYQVG VFISRSSTPF FRIHDLYLPS
FLQILNLVLL TLQAVFNFIP SVYIIFIIIF WEGLLGGLVY VNTFAEIGDR VPKEDREFSL
GATTVSDAAG ICIAGFVSMV FEVWLCDWQV THGRDYCRRI
