BTN1_CANAL
ID BTN1_CANAL Reviewed; 426 AA.
AC Q59LX9; A0A1D8PDG8; Q59LY9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Protein BTN1;
DE Flags: Precursor;
GN Name=BTN1; OrderedLocusNames=CAALFM_C105120WA;
GN ORFNames=CaO19.11541, CaO19.4059;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Involved in vacuolar transport and vacuole pH homeostasis.
CC Also required for cytokinesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26183.1; -; Genomic_DNA.
DR RefSeq; XP_710728.2; XM_705636.2.
DR AlphaFoldDB; Q59LX9; -.
DR SMR; Q59LX9; -.
DR STRING; 237561.Q59LX9; -.
DR TCDB; 2.A.57.5.3; the equilibrative nucleoside transporter (ent) family.
DR PRIDE; Q59LX9; -.
DR GeneID; 3647667; -.
DR KEGG; cal:CAALFM_C105120WA; -.
DR CGD; CAL0000190783; orf19.11541.
DR VEuPathDB; FungiDB:C1_05120W_A; -.
DR eggNOG; KOG3880; Eukaryota.
DR HOGENOM; CLU_029663_1_2_1; -.
DR InParanoid; Q59LX9; -.
DR OrthoDB; 1037817at2759; -.
DR PRO; PR:Q59LX9; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0000324; C:fungal-type vacuole; IEA:EnsemblFungi.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:1903826; P:L-arginine transmembrane transport; IEA:EnsemblFungi.
DR GO; GO:0015819; P:lysine transport; IEA:EnsemblFungi.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR003492; Battenin_disease_Cln3.
DR InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10981; PTHR10981; 1.
DR Pfam; PF02487; CLN3; 1.
DR PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR PRINTS; PR01315; BATTENIN.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport; Vacuole.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..426
FT /note="Protein BTN1"
FT /id="PRO_0000256257"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 426 AA; 48162 MW; 428F8D304F0CC9BF CRC64;
MFIISETQRT FASFFIFGLL NNILYVIILS AAIDLVGPST PKAIVLLADI IPSFSFKVAA
PFFIHAVPYI IRLWTLVALS ATGMVLISLS PTNVISWKIL GITLASLSSG LGEVSFLQLT
HYYEENSAIG GFSSGTGGAG LFGSFLFMVL TNVMGFPVWV VLLICAVFPS GFIITYFNLL
PLPMHEYQVI LQQQQEREEE QEEEEYQQQL QDEARSQNIE SIREVKYSVN YISKHVQNTI
HKITPLILPY MLPLTTVYIS EYVINQGISP TLLFPLKEVP RWLISSYRDI YVVYGFLYQL
GVFISRSSVT MGIRIKRLYL LSVLQFINVM ITLYQSIYDL PFHSIWWLFL LIFYEGLLGG
ASYVNTFKSV SEQVSRTKRE FSMGCVSISD SLGIVTAGCI NWWLELKLCH LQVARGRDWC
LKGGSL
