ID   TOLB_FRAT1              Reviewed;         439 AA.
AC   Q14HZ9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE   Flags: Precursor;
GN   Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=FTF0840;
OS   Francisella tularensis subsp. tularensis (strain FSC 198).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=393115;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FSC 198;
RX   PubMed=17406676; DOI=10.1371/journal.pone.0000352;
RA   Chaudhuri R.R., Ren C.-P., Desmond L., Vincent G.A., Silman N.J.,
RA   Brehm J.K., Elmore M.J., Hudson M.J., Forsman M., Isherwood K.E.,
RA   Gurycova D., Minton N.P., Titball R.W., Pallen M.J., Vipond R.;
RT   "Genome sequencing shows that European isolates of Francisella tularensis
RT   subspecies tularensis are almost identical to US laboratory strain Schu
RT   S4.";
RL   PLoS ONE 2:E352-E352(2007).
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
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DR   EMBL; AM286280; CAL08856.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q14HZ9; -.
DR   SMR; Q14HZ9; -.
DR   KEGG; ftf:FTF0840; -.
DR   HOGENOM; CLU_047123_0_0_6; -.
DR   OMA; DIYGPGQ; -.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0017038; P:protein import; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 1.
DR   HAMAP; MF_00671; TolB; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR014167; Tol-Pal_TolB.
DR   Pfam; PF07676; PD40; 3.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Periplasm; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT   CHAIN           25..439
FT                   /note="Tol-Pal system protein TolB"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT                   /id="PRO_0000259049"
SQ   SEQUENCE   439 AA;  48865 MW;  3016AE59644A1AF8 CRC64;
     MRNGMRKIIA GVFIFVFLIS NLYADLVAEV TTGVIQKPLV TVVSDNVVDQ FPQQVNSVIV
     ADLNHNAKLQ ANDTIKYEIK QKQNIPWKSL KSDYVVLTKY TNNSYNNYTV EVQILKRNDT
     SYLQAITYKN INVSLMRTLA HKISNYVYQK LTGNQGFFLT KLAYVKVSNP YARYGRLYEL
     IISDYDGYNK HVVLRQTDNP IATPSWSNDG RYIVYSSYSG GSMGVYTLEI ATGKVTRITN
     YKGINSSPSF SPDGKEIALA LSKGYSDQTN IYIMNLSTKA LKRITINGIN TAPKFSPNGQ
     SIVFTSDREG RPNIYVASVN SKYPQSSILS TKIHQAYEPN YTPDGKNIVF MNQSSRTSGT
     QIADFNLANG SVTNITNGKA DSSPTVSPYG DMVAYISTNT RGYSSLDMVS LDGDNHFNIE
     TADNGNILIQ SPSWSPKNF