TOLB_FRAT1
ID TOLB_FRAT1 Reviewed; 439 AA.
AC Q14HZ9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE Flags: Precursor;
GN Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=FTF0840;
OS Francisella tularensis subsp. tularensis (strain FSC 198).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=393115;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSC 198;
RX PubMed=17406676; DOI=10.1371/journal.pone.0000352;
RA Chaudhuri R.R., Ren C.-P., Desmond L., Vincent G.A., Silman N.J.,
RA Brehm J.K., Elmore M.J., Hudson M.J., Forsman M., Isherwood K.E.,
RA Gurycova D., Minton N.P., Titball R.W., Pallen M.J., Vipond R.;
RT "Genome sequencing shows that European isolates of Francisella tularensis
RT subspecies tularensis are almost identical to US laboratory strain Schu
RT S4.";
RL PLoS ONE 2:E352-E352(2007).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
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DR EMBL; AM286280; CAL08856.1; -; Genomic_DNA.
DR AlphaFoldDB; Q14HZ9; -.
DR SMR; Q14HZ9; -.
DR KEGG; ftf:FTF0840; -.
DR HOGENOM; CLU_047123_0_0_6; -.
DR OMA; DIYGPGQ; -.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR HAMAP; MF_00671; TolB; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR014167; Tol-Pal_TolB.
DR Pfam; PF07676; PD40; 3.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Periplasm; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT CHAIN 25..439
FT /note="Tol-Pal system protein TolB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT /id="PRO_0000259049"
SQ SEQUENCE 439 AA; 48865 MW; 3016AE59644A1AF8 CRC64;
MRNGMRKIIA GVFIFVFLIS NLYADLVAEV TTGVIQKPLV TVVSDNVVDQ FPQQVNSVIV
ADLNHNAKLQ ANDTIKYEIK QKQNIPWKSL KSDYVVLTKY TNNSYNNYTV EVQILKRNDT
SYLQAITYKN INVSLMRTLA HKISNYVYQK LTGNQGFFLT KLAYVKVSNP YARYGRLYEL
IISDYDGYNK HVVLRQTDNP IATPSWSNDG RYIVYSSYSG GSMGVYTLEI ATGKVTRITN
YKGINSSPSF SPDGKEIALA LSKGYSDQTN IYIMNLSTKA LKRITINGIN TAPKFSPNGQ
SIVFTSDREG RPNIYVASVN SKYPQSSILS TKIHQAYEPN YTPDGKNIVF MNQSSRTSGT
QIADFNLANG SVTNITNGKA DSSPTVSPYG DMVAYISTNT RGYSSLDMVS LDGDNHFNIE
TADNGNILIQ SPSWSPKNF