TOLB_FRATM
ID TOLB_FRATM Reviewed; 435 AA.
AC B2SET5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE Flags: Precursor;
GN Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=FTM_0432;
OS Francisella tularensis subsp. mediasiatica (strain FSC147).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=441952;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSC147;
RX PubMed=19521508; DOI=10.1371/journal.ppat.1000472;
RA Larsson P., Elfsmark D., Svensson K., Wikstroem P., Forsman M., Brettin T.,
RA Keim P., Johansson A.;
RT "Molecular evolutionary consequences of niche restriction in Francisella
RT tularensis, a facultative intracellular pathogen.";
RL PLoS Pathog. 5:E1000472-E1000472(2009).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
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DR EMBL; CP000915; ACD30461.1; -; Genomic_DNA.
DR AlphaFoldDB; B2SET5; -.
DR SMR; B2SET5; -.
DR KEGG; ftm:FTM_0432; -.
DR HOGENOM; CLU_047123_0_0_6; -.
DR OMA; DIYGPGQ; -.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR HAMAP; MF_00671; TolB; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR014167; Tol-Pal_TolB.
DR Pfam; PF07676; PD40; 3.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Periplasm; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT CHAIN 21..435
FT /note="Tol-Pal system protein TolB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT /id="PRO_1000131530"
SQ SEQUENCE 435 AA; 48437 MW; 2CF962BF092CAB36 CRC64;
MRKIIAGVFI FVFLISNLYA DLVAEVTTGV IQKPLVTVVS DNVVDQFPQQ VNFVIVADLN
HNAKLQANDT IKYEIKQKQN IPWKSLKSDY VVLTKYTNNS YNNYTVEVQI LKRNDTSYLQ
AITYKNINVS LMRALAHKIS NYVYQKLTGN QGFFLTKLAY VKVSNPYARY GRLYELIISD
YDGYNKHVVL RQTDNPIATP SWSNDGRYIV YSSYSGGSMG VYTLEIATGK VTRITNYKGI
NSSPSFSPDG KEIALALSKG YSDQTNIYIM NLSTKALKRI TINGINTAPK FSPNGQSIVF
TSDREGRPNI YVASVNSKYP QSSILSTKIH QAYEPNYTPD GKNIVFMNQS SRTSGTQIAD
FNLANGSVTN ITNGKADSSP TVSPYGDMVA YISTNTRGYS SLDMVSLDGD NHFNIETADN
GNILIQSPSW SPKNF