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TOLB_FRATN
ID   TOLB_FRATN              Reviewed;         435 AA.
AC   A0Q4U6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE   Flags: Precursor;
GN   Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=FTN_0355;
OS   Francisella tularensis subsp. novicida (strain U112).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=401614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=U112;
RX   PubMed=17550600; DOI=10.1186/gb-2007-8-6-r102;
RA   Rohmer L., Fong C., Abmayr S., Wasnick M., Larson Freeman T.J., Radey M.,
RA   Guina T., Svensson K., Hayden H.S., Jacobs M., Gallagher L.A., Manoil C.,
RA   Ernst R.K., Drees B., Buckley D., Haugen E., Bovee D., Zhou Y., Chang J.,
RA   Levy R., Lim R., Gillett W., Guenthener D., Kang A., Shaffer S.A.,
RA   Taylor G., Chen J., Gallis B., D'Argenio D.A., Forsman M., Olson M.V.,
RA   Goodlett D.R., Kaul R., Miller S.I., Brittnacher M.J.;
RT   "Comparison of Francisella tularensis genomes reveals evolutionary events
RT   associated with the emergence of human pathogenic strains.";
RL   Genome Biol. 8:R102.1-R102.16(2007).
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
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DR   EMBL; CP000439; ABK89261.1; -; Genomic_DNA.
DR   RefSeq; WP_003038375.1; NZ_CP009633.1.
DR   AlphaFoldDB; A0Q4U6; -.
DR   SMR; A0Q4U6; -.
DR   EnsemblBacteria; ABK89261; ABK89261; FTN_0355.
DR   KEGG; ftn:FTN_0355; -.
DR   OMA; DIYGPGQ; -.
DR   Proteomes; UP000000762; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0017038; P:protein import; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 1.
DR   HAMAP; MF_00671; TolB; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR014167; Tol-Pal_TolB.
DR   Pfam; PF07676; PD40; 3.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Periplasm; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT   CHAIN           21..435
FT                   /note="Tol-Pal system protein TolB"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT                   /id="PRO_1000061937"
SQ   SEQUENCE   435 AA;  48329 MW;  F5E270FD979D74D3 CRC64;
     MRKIIAGVSI FVFLISNLYA DLVAEVTTGV IQKPLVTVVS DNVVDQFPQQ VNSVIVADLN
     HNAKLQANDT IKYEIKQKQN IPWKSLKSDY VVLTKYTKNA YNNYTVEVQI LKRNDTSYLQ
     AITYKNINVS LMRTLAHKIS NYVYQKLTGN QGFFLTKLAY VKVSNPYARY GRLYELIISD
     YDGYNKHVVL RQTDNPIATP SWSNDGRYIV YSSYSGGSMG VYTLEIATGK VTRITNYKGI
     NSSPSFSPDG KEIALALSKG YSDQTNIYIM NLATKALKRI TINGINTAPK FSPNGQSIVF
     TSDREGRPNI YVASVNSKYP QSSILSTKIH QAYEPNYTPD GKNIVFMNQS SRTSGTQIAD
     FNLANGSVTN ITNGKADSSP TVSPYGDMVA YISTNTRGYS SLDMVSLDGD NHFNIETADN
     GNILIQSPSW SPKNF
 
 
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