ID   BTN1_CANGA              Reviewed;         411 AA.
AC   Q6FPB6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Protein BTN1;
DE   Flags: Precursor;
GN   Name=BTN1; OrderedLocusNames=CAGL0J05104g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in vacuolar transport and vacuole pH homeostasis.
CC       Also required for cytokinesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
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DR   EMBL; CR380956; CAG60877.1; -; Genomic_DNA.
DR   RefSeq; XP_447928.1; XM_447928.1.
DR   AlphaFoldDB; Q6FPB6; -.
DR   SMR; Q6FPB6; -.
DR   STRING; 5478.XP_447928.1; -.
DR   EnsemblFungi; CAG60877; CAG60877; CAGL0J05104g.
DR   GeneID; 2889499; -.
DR   KEGG; cgr:CAGL0J05104g; -.
DR   CGD; CAL0133534; CAGL0J05104g.
DR   VEuPathDB; FungiDB:CAGL0J05104g; -.
DR   eggNOG; KOG3880; Eukaryota.
DR   HOGENOM; CLU_029663_1_2_1; -.
DR   InParanoid; Q6FPB6; -.
DR   OMA; WLCNWQV; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0000324; C:fungal-type vacuole; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1903826; P:L-arginine transmembrane transport; IEA:EnsemblFungi.
DR   GO; GO:0015819; P:lysine transport; IEA:EnsemblFungi.
DR   GO; GO:0051453; P:regulation of intracellular pH; IEA:EnsemblFungi.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR003492; Battenin_disease_Cln3.
DR   InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10981; PTHR10981; 1.
DR   Pfam; PF02487; CLN3; 1.
DR   PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR   PRINTS; PR01315; BATTENIN.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..411
FT                   /note="Protein BTN1"
FT                   /id="PRO_0000256258"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   411 AA;  45826 MW;  6E7A50B81A0B2EF8 CRC64;
     MNSKQRVYAF FWIFGLVNNV LYVVILSAAV DIVGPKVPKT LVLLMDITPS LLIKVTAPFF
     IKSIPYTMRI YALIALSCIG MIFVSGKSLL LCMIGIAMAS VSSGFGEVSF LQLSHFFEEN
     ALNGWSSGTG GAGIVGSSVY MLLTSIFKLP IRLSLLSFTI LPFAFLLYFK LDTTQIEYDS
     ISSSGEETLI RNSNSNALQT DTFNESIRLS KTEEQNIFVS SIDHFKSTCV NLKALVVPYM
     LPLSSVYLFE YLINQAVSPT LLFPLDSRGL PPFFNKYRDM YVTYGTLYQL GVFISRSLAH
     KFRMHNLYFL SALQGLNLVL TILQAWIYIV HTPWPIMILI FYEGLLGGSS YVNTFLNVLE
     EVDMDKREFS LGAVSIADSL GVFIAALVGL GLEPTICNHQ VSTGRPWCRM E