TOLB_FRATT
ID TOLB_FRATT Reviewed; 439 AA.
AC Q5NGJ7;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE Flags: Precursor;
GN Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=FTT_0840;
OS Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=177416;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCHU S4 / Schu 4;
RX PubMed=15640799; DOI=10.1038/ng1499;
RA Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H.,
RA Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D.,
RA Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S.,
RA Sjoestedt A., Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W.,
RA Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W.;
RT "The complete genome sequence of Francisella tularensis, the causative
RT agent of tularemia.";
RL Nat. Genet. 37:153-159(2005).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
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DR EMBL; AJ749949; CAG45473.1; -; Genomic_DNA.
DR RefSeq; YP_169845.1; NC_006570.2.
DR AlphaFoldDB; Q5NGJ7; -.
DR SMR; Q5NGJ7; -.
DR STRING; 177416.FTT_0840; -.
DR DNASU; 3190788; -.
DR EnsemblBacteria; CAG45473; CAG45473; FTT_0840.
DR KEGG; ftu:FTT_0840; -.
DR eggNOG; COG0823; Bacteria.
DR OMA; DIYGPGQ; -.
DR Proteomes; UP000001174; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR HAMAP; MF_00671; TolB; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR014167; Tol-Pal_TolB.
DR Pfam; PF07676; PD40; 3.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT CHAIN 25..439
FT /note="Tol-Pal system protein TolB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT /id="PRO_0000034652"
SQ SEQUENCE 439 AA; 48865 MW; 3016AE59644A1AF8 CRC64;
MRNGMRKIIA GVFIFVFLIS NLYADLVAEV TTGVIQKPLV TVVSDNVVDQ FPQQVNSVIV
ADLNHNAKLQ ANDTIKYEIK QKQNIPWKSL KSDYVVLTKY TNNSYNNYTV EVQILKRNDT
SYLQAITYKN INVSLMRTLA HKISNYVYQK LTGNQGFFLT KLAYVKVSNP YARYGRLYEL
IISDYDGYNK HVVLRQTDNP IATPSWSNDG RYIVYSSYSG GSMGVYTLEI ATGKVTRITN
YKGINSSPSF SPDGKEIALA LSKGYSDQTN IYIMNLSTKA LKRITINGIN TAPKFSPNGQ
SIVFTSDREG RPNIYVASVN SKYPQSSILS TKIHQAYEPN YTPDGKNIVF MNQSSRTSGT
QIADFNLANG SVTNITNGKA DSSPTVSPYG DMVAYISTNT RGYSSLDMVS LDGDNHFNIE
TADNGNILIQ SPSWSPKNF