ID   TOLB_HAEIN              Reviewed;         427 AA.
AC   P44677; P94811;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE   Flags: Precursor;
GN   Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=HI_0382;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1479;
RX   PubMed=8921895; DOI=10.1016/0378-1119(96)00338-1;
RA   Sen K., Sikkema D.J., Murphy T.F.;
RT   "Isolation and characterization of the Haemophilus influenzae tolQ, tolR,
RT   tolA and tolB genes.";
RL   Gene 178:75-81(1996).
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671,
CC       ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00671, ECO:0000305}.
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DR   EMBL; L42023; AAC22040.1; -; Genomic_DNA.
DR   EMBL; U32470; AAC44597.1; -; Genomic_DNA.
DR   PIR; F64064; F64064.
DR   RefSeq; NP_438543.1; NC_000907.1.
DR   RefSeq; WP_005693786.1; NC_000907.1.
DR   AlphaFoldDB; P44677; -.
DR   SMR; P44677; -.
DR   STRING; 71421.HI_0382; -.
DR   EnsemblBacteria; AAC22040; AAC22040; HI_0382.
DR   KEGG; hin:HI_0382; -.
DR   PATRIC; fig|71421.8.peg.400; -.
DR   eggNOG; COG0823; Bacteria.
DR   HOGENOM; CLU_047123_0_0_6; -.
DR   OMA; VREPSWG; -.
DR   PhylomeDB; P44677; -.
DR   BioCyc; HINF71421:G1GJ1-397-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0017038; P:protein import; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 1.
DR   HAMAP; MF_00671; TolB; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR014167; Tol-Pal_TolB.
DR   InterPro; IPR007195; TolB_N.
DR   Pfam; PF07676; PD40; 4.
DR   Pfam; PF04052; TolB_N; 1.
DR   TIGRFAMs; TIGR02800; propeller_TolB; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT   CHAIN           24..427
FT                   /note="Tol-Pal system protein TolB"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT                   /id="PRO_0000034656"
FT   VARIANT         6
FT                   /note="R -> H (in strain: 1479)"
FT   VARIANT         14
FT                   /note="V -> I (in strain: 1479)"
FT   VARIANT         17..19
FT                   /note="VGS -> ITH (in strain: 1479)"
FT   VARIANT         21
FT                   /note="A -> V (in strain: 1479)"
FT   VARIANT         79
FT                   /note="R -> H (in strain: 1479)"
FT   VARIANT         129
FT                   /note="T -> A (in strain: 1479)"
FT   VARIANT         160
FT                   /note="A -> G (in strain: 1479)"
FT   VARIANT         237
FT                   /note="A -> T (in strain: 1479)"
FT   VARIANT         322
FT                   /note="S -> N (in strain: 1479)"
FT   VARIANT         326
FT                   /note="A -> V (in strain: 1479)"
FT   VARIANT         328
FT                   /note="A -> S (in strain: 1479)"
SQ   SEQUENCE   427 AA;  44968 MW;  0882201AEE9254B9 CRC64;
     MKLLKRLVSV FAIVLAVGSN AFAGDEVRIV IDEGVDGARP IAVVPFVGSA PEDISKIVAD
     DLRNSGKFNP IAVSQMPQRP TSAAEVNPEA WSNIGIDAIV IGQVVPSGNG YSITYQLIDT
     VGASGTPGTV LMQNSYTVTN KWLRYGAHTV SDEVFEKLTA IRGAFRTRIA YVVQKNGGSQ
     PYEVRVADYD GYNQFIVNRS AQPIMSPAWS PDGQRLAYVS FENKKSQLVV QDLNSGARKV
     VASFQGHNGA PAFSPDGSRL AFASSRDGVL NIYVMGANGG TPTQLTSGAG NNTEPAWSPD
     GNSILFTSDR SGSPQVYRMD ASGGSATAVG GRGSAQISAD GKTLVMINGN NNVVKQDLTT
     GVSEVLSTSF LGESPSLSPN GIMIIYSSTQ GLGKVLQLVS ADGRFKASLP GSDGQVKFPA
     WSPYLTK