TOLB_HAMD5
ID TOLB_HAMD5 Reviewed; 429 AA.
AC C4K8V2;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE Flags: Precursor;
GN Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=HDEF_0166;
OS Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; aphid secondary symbionts; Candidatus Hamiltonella.
OX NCBI_TaxID=572265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5AT;
RX PubMed=19451630; DOI=10.1073/pnas.0900194106;
RA Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.;
RT "Hamiltonella defensa, genome evolution of protective bacterial
RT endosymbiont from pathogenic ancestors.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009).
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. TolB occupies a key intermediary
CC position in the Tol-Pal system because it communicates directly with
CC both membrane-embedded components, Pal in the outer membrane and TolA
CC in the inner membrane. {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
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DR EMBL; CP001277; ACQ66939.1; -; Genomic_DNA.
DR RefSeq; WP_012737904.1; NC_012751.1.
DR AlphaFoldDB; C4K8V2; -.
DR SMR; C4K8V2; -.
DR STRING; 572265.HDEF_0166; -.
DR PRIDE; C4K8V2; -.
DR EnsemblBacteria; ACQ66939; ACQ66939; HDEF_0166.
DR GeneID; 66260101; -.
DR KEGG; hde:HDEF_0166; -.
DR eggNOG; COG0823; Bacteria.
DR HOGENOM; CLU_047123_0_0_6; -.
DR OMA; VREPSWG; -.
DR Proteomes; UP000002334; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR HAMAP; MF_00671; TolB; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR014167; Tol-Pal_TolB.
DR InterPro; IPR007195; TolB_N.
DR Pfam; PF07676; PD40; 3.
DR Pfam; PF04052; TolB_N; 1.
DR TIGRFAMs; TIGR02800; propeller_TolB; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT CHAIN 22..429
FT /note="Tol-Pal system protein TolB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT /id="PRO_1000212509"
SQ SEQUENCE 429 AA; 47229 MW; 37E4E855801E0BCC CRC64;
MKPVFKMLLS LLILWTSLLH AQVRIQITQG VDSARPIAVV PFKWLGTVEP PEKIADIISS
DLRNSGKFNP IDPSRMPEKP FTASELITSS WYGLGVDAVV VGQIQAGADN HYLISYQLVE
LSSGTVLTQN QYKVTQQWLR YAAHSASDEI FQKLTGIKGA FSTRIAYVVQ KNTRQLPYEL
KISDYDGYNP FVVYRSSQPL MSPAWSPDGQ KLAYVNFESG RSALVIQNLA SGSIQKIANF
QGHNGAPAFS PDGAKLAFAL SKTGSLNIYM MDLASGNITQ ITDSRSNNTE PSWFPDSRYL
AYTSDQAGRP QVYKIDISGH GVPQRITWNA KQNQNSAVSP DGTFLILVNS KDGQQHIAKQ
DLKTGDVQIL TDTLLDETPS IAPNTTMVIY SSTQNANSVL QLVSTDGRFK ALLPEVDGQV
KFPAWSPYL