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TOLB_HAMD5
ID   TOLB_HAMD5              Reviewed;         429 AA.
AC   C4K8V2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE   Flags: Precursor;
GN   Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=HDEF_0166;
OS   Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; aphid secondary symbionts; Candidatus Hamiltonella.
OX   NCBI_TaxID=572265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5AT;
RX   PubMed=19451630; DOI=10.1073/pnas.0900194106;
RA   Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.;
RT   "Hamiltonella defensa, genome evolution of protective bacterial
RT   endosymbiont from pathogenic ancestors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009).
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. TolB occupies a key intermediary
CC       position in the Tol-Pal system because it communicates directly with
CC       both membrane-embedded components, Pal in the outer membrane and TolA
CC       in the inner membrane. {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
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DR   EMBL; CP001277; ACQ66939.1; -; Genomic_DNA.
DR   RefSeq; WP_012737904.1; NC_012751.1.
DR   AlphaFoldDB; C4K8V2; -.
DR   SMR; C4K8V2; -.
DR   STRING; 572265.HDEF_0166; -.
DR   PRIDE; C4K8V2; -.
DR   EnsemblBacteria; ACQ66939; ACQ66939; HDEF_0166.
DR   GeneID; 66260101; -.
DR   KEGG; hde:HDEF_0166; -.
DR   eggNOG; COG0823; Bacteria.
DR   HOGENOM; CLU_047123_0_0_6; -.
DR   OMA; VREPSWG; -.
DR   Proteomes; UP000002334; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0017038; P:protein import; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 1.
DR   HAMAP; MF_00671; TolB; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR014167; Tol-Pal_TolB.
DR   InterPro; IPR007195; TolB_N.
DR   Pfam; PF07676; PD40; 3.
DR   Pfam; PF04052; TolB_N; 1.
DR   TIGRFAMs; TIGR02800; propeller_TolB; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT   CHAIN           22..429
FT                   /note="Tol-Pal system protein TolB"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT                   /id="PRO_1000212509"
SQ   SEQUENCE   429 AA;  47229 MW;  37E4E855801E0BCC CRC64;
     MKPVFKMLLS LLILWTSLLH AQVRIQITQG VDSARPIAVV PFKWLGTVEP PEKIADIISS
     DLRNSGKFNP IDPSRMPEKP FTASELITSS WYGLGVDAVV VGQIQAGADN HYLISYQLVE
     LSSGTVLTQN QYKVTQQWLR YAAHSASDEI FQKLTGIKGA FSTRIAYVVQ KNTRQLPYEL
     KISDYDGYNP FVVYRSSQPL MSPAWSPDGQ KLAYVNFESG RSALVIQNLA SGSIQKIANF
     QGHNGAPAFS PDGAKLAFAL SKTGSLNIYM MDLASGNITQ ITDSRSNNTE PSWFPDSRYL
     AYTSDQAGRP QVYKIDISGH GVPQRITWNA KQNQNSAVSP DGTFLILVNS KDGQQHIAKQ
     DLKTGDVQIL TDTLLDETPS IAPNTTMVIY SSTQNANSVL QLVSTDGRFK ALLPEVDGQV
     KFPAWSPYL
 
 
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