ID   TOLB_HELPY              Reviewed;         417 AA.
AC   O25751; Q9RNF5;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE   Flags: Precursor;
GN   Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=HP_1126;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RU-1;
RA   Kolesnikow T., Gekas S., Lee A.;
RT   "Identification of Helicobacter pylori antigens.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
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DR   EMBL; AE000511; AAD08170.1; -; Genomic_DNA.
DR   EMBL; AF181881; AAF04275.1; -; Genomic_DNA.
DR   PIR; F64660; F64660.
DR   RefSeq; NP_207917.1; NC_000915.1.
DR   RefSeq; WP_001269995.1; NC_018939.1.
DR   AlphaFoldDB; O25751; -.
DR   SMR; O25751; -.
DR   STRING; 85962.C694_05815; -.
DR   PaxDb; O25751; -.
DR   EnsemblBacteria; AAD08170; AAD08170; HP_1126.
DR   KEGG; hpy:HP_1126; -.
DR   PATRIC; fig|85962.47.peg.1209; -.
DR   eggNOG; COG0823; Bacteria.
DR   OMA; DIYGPGQ; -.
DR   PhylomeDB; O25751; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0017038; P:protein import; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 1.
DR   HAMAP; MF_00671; TolB; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR014167; Tol-Pal_TolB.
DR   Pfam; PF07676; PD40; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT   CHAIN           17..417
FT                   /note="Tol-Pal system protein TolB"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT                   /id="PRO_0000034658"
FT   CONFLICT        10
FT                   /note="H -> C (in Ref. 2; AAF04275)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        58
FT                   /note="K -> R (in Ref. 2; AAF04275)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        109..114
FT                   /note="DTGTLK -> NTSALV (in Ref. 2; AAF04275)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        122..124
FT                   /note="VSL -> LSA (in Ref. 2; AAF04275)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        353
FT                   /note="T -> A (in Ref. 2; AAF04275)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        387
FT                   /note="P -> S (in Ref. 2; AAF04275)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   417 AA;  47798 MW;  05428A5B251EDBE5 CRC64;
     MRYLWLFLIH TIGLFATDKT LDIIKTIQKL PKIEVRYSID NDANYALKLH EVLANDLKTS
     QHFDVSQNKD QGAINYAELK DKKVHLVALV SVAVENGNKI SRLKLYDVDT GTLKKTFDYP
     IVSLDLYPFA AHNMAIVVND YLKAPSIAWM KRLIVFSKYI GPGITNIALA DYTMRYQKEI
     IKNNRLNIFP KWANAEQTEF YYTQYGERTP MILKYNIQKA THENIASSQG MAVVSSVSSD
     GSKILMSLAP DGQPDVYLYD THKKTKTKIT RYPGIDVSGV FLEDDKSMAF VSDRSGYPNI
     YMKKLGLKES AEQLLYEGRS NESIDAYKDS IVYVSRENLN EFGKTVFNLN LITLNSKYIR
     RLTVNGSNQM PRFSTDGRNI MYIKKTPQEY AMGLILLDYN QSFLFPLKNV KIQAFDW