TOLB_HELPY
ID TOLB_HELPY Reviewed; 417 AA.
AC O25751; Q9RNF5;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE Flags: Precursor;
GN Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671}; OrderedLocusNames=HP_1126;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RU-1;
RA Kolesnikow T., Gekas S., Lee A.;
RT "Identification of Helicobacter pylori antigens.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC membrane invagination during cell division and is important for
CC maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
CC -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC TolB and the outer membrane protein Pal. They form a network linking
CC the inner and outer membranes and the peptidoglycan layer.
CC {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC Rule:MF_00671}.
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DR EMBL; AE000511; AAD08170.1; -; Genomic_DNA.
DR EMBL; AF181881; AAF04275.1; -; Genomic_DNA.
DR PIR; F64660; F64660.
DR RefSeq; NP_207917.1; NC_000915.1.
DR RefSeq; WP_001269995.1; NC_018939.1.
DR AlphaFoldDB; O25751; -.
DR SMR; O25751; -.
DR STRING; 85962.C694_05815; -.
DR PaxDb; O25751; -.
DR EnsemblBacteria; AAD08170; AAD08170; HP_1126.
DR KEGG; hpy:HP_1126; -.
DR PATRIC; fig|85962.47.peg.1209; -.
DR eggNOG; COG0823; Bacteria.
DR OMA; DIYGPGQ; -.
DR PhylomeDB; O25751; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR HAMAP; MF_00671; TolB; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR014167; Tol-Pal_TolB.
DR Pfam; PF07676; PD40; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT CHAIN 17..417
FT /note="Tol-Pal system protein TolB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT /id="PRO_0000034658"
FT CONFLICT 10
FT /note="H -> C (in Ref. 2; AAF04275)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="K -> R (in Ref. 2; AAF04275)"
FT /evidence="ECO:0000305"
FT CONFLICT 109..114
FT /note="DTGTLK -> NTSALV (in Ref. 2; AAF04275)"
FT /evidence="ECO:0000305"
FT CONFLICT 122..124
FT /note="VSL -> LSA (in Ref. 2; AAF04275)"
FT /evidence="ECO:0000305"
FT CONFLICT 353
FT /note="T -> A (in Ref. 2; AAF04275)"
FT /evidence="ECO:0000305"
FT CONFLICT 387
FT /note="P -> S (in Ref. 2; AAF04275)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 47798 MW; 05428A5B251EDBE5 CRC64;
MRYLWLFLIH TIGLFATDKT LDIIKTIQKL PKIEVRYSID NDANYALKLH EVLANDLKTS
QHFDVSQNKD QGAINYAELK DKKVHLVALV SVAVENGNKI SRLKLYDVDT GTLKKTFDYP
IVSLDLYPFA AHNMAIVVND YLKAPSIAWM KRLIVFSKYI GPGITNIALA DYTMRYQKEI
IKNNRLNIFP KWANAEQTEF YYTQYGERTP MILKYNIQKA THENIASSQG MAVVSSVSSD
GSKILMSLAP DGQPDVYLYD THKKTKTKIT RYPGIDVSGV FLEDDKSMAF VSDRSGYPNI
YMKKLGLKES AEQLLYEGRS NESIDAYKDS IVYVSRENLN EFGKTVFNLN LITLNSKYIR
RLTVNGSNQM PRFSTDGRNI MYIKKTPQEY AMGLILLDYN QSFLFPLKNV KIQAFDW