ID   BTN1_CRYNB              Reviewed;         517 AA.
AC   P0CM43; Q55QB2; Q5KFV4;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Protein BTN1;
GN   Name=BTN1; OrderedLocusNames=CNBF4250;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in vacuolar transport and vacuole pH homeostasis.
CC       Also required for cytokinesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
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DR   EMBL; AAEY01000032; EAL20099.1; -; Genomic_DNA.
DR   RefSeq; XP_774746.1; XM_769653.1.
DR   AlphaFoldDB; P0CM43; -.
DR   EnsemblFungi; EAL20099; EAL20099; CNBF4250.
DR   GeneID; 4936977; -.
DR   KEGG; cnb:CNBF4250; -.
DR   VEuPathDB; FungiDB:CNBF4250; -.
DR   HOGENOM; CLU_029663_3_1_1; -.
DR   Proteomes; UP000001435; Chromosome 6.
DR   GO; GO:0032153; C:cell division site; IEA:EnsemblFungi.
DR   GO; GO:0051286; C:cell tip; IEA:EnsemblFungi.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003492; Battenin_disease_Cln3.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10981; PTHR10981; 1.
DR   Pfam; PF02487; CLN3; 1.
DR   PRINTS; PR01315; BATTENIN.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Transmembrane; Transmembrane helix;
KW   Transport; Vacuole.
FT   CHAIN           1..517
FT                   /note="Protein BTN1"
FT                   /id="PRO_0000410023"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   517 AA;  56759 MW;  66DA2BCB71DC82FB CRC64;
     MDKDNQALDE LPMMTGSKHA NKRLFAAFMI FGLLNNVLYV IILSAALDLV SADTPKGVVA
     LFNIFPALIT KVVWPLLSNG KIRYTRRVGF CTICSWFGII TIALSSSLSP RLLGISLASL
     SSGMGELTFL QLTTTLPTEA TSKTALGAWS SGTGFAGVAG AGIWWLLRGL GVKGGLGLSS
     FLPLFFPITY KYILPPFSHL EASSDSSPYQ RLPTSSSLSN NNNFRPPAIL ISVPSSEYVP
     QHTPLLSSGF IDRDRDRNRD GEELTDGDKR LMGMRASRLT TQEKMKLLRP LVVRYMLPLC
     AVYVEEYVIN SGVAPTLVFP LPTYGLWSWL FKSPRDYYPF WSLTYQTFVF LSRSSLSLGL
     PPIPKRLLPL PAIIQFLVLS LLFLQAKTFF FSSPAYTPPA DGDGGVDRSI TIVFLLICLE
     GLCGGSGYVN TFYHVGREGS SVSENYDADG ENEMGGDRRT LNVTEMEKKA MEREFRIGAV
     GAADSTGILF ASLISMPLEI ALCRSQVDQG RTMCREL