ID   BTN1_CRYNJ              Reviewed;         516 AA.
AC   P0CM42; Q55QB2; Q5KFV4;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Protein BTN1;
GN   Name=BTN1; OrderedLocusNames=CNF00440;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in vacuolar transport and vacuole pH homeostasis.
CC       Also required for cytokinesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017346; AAW44170.1; -; Genomic_DNA.
DR   RefSeq; XP_571477.1; XM_571477.1.
DR   AlphaFoldDB; P0CM42; -.
DR   STRING; 5207.AAW44170; -.
DR   PaxDb; P0CM42; -.
DR   EnsemblFungi; AAW44170; AAW44170; CNF00440.
DR   GeneID; 3258156; -.
DR   KEGG; cne:CNF00440; -.
DR   VEuPathDB; FungiDB:CNF00440; -.
DR   eggNOG; KOG3880; Eukaryota.
DR   HOGENOM; CLU_029663_3_1_1; -.
DR   InParanoid; P0CM42; -.
DR   OMA; WLCNWQV; -.
DR   OrthoDB; 1037817at2759; -.
DR   Proteomes; UP000002149; Chromosome 6.
DR   GO; GO:0032153; C:cell division site; IEA:EnsemblFungi.
DR   GO; GO:0051286; C:cell tip; IEA:EnsemblFungi.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR   InterPro; IPR003492; Battenin_disease_Cln3.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10981; PTHR10981; 1.
DR   Pfam; PF02487; CLN3; 1.
DR   PRINTS; PR01315; BATTENIN.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..516
FT                   /note="Protein BTN1"
FT                   /id="PRO_0000256260"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   516 AA;  56656 MW;  3BA31235477E449C CRC64;
     MDKDNQALDE LPMLTGSKHA NKRLFAAFMI FGLLNNVLYV IILSAALDLV SADTPKGVVA
     LFNIFPALIT KVVWPLLSNG KIRYTRRVGF CTICSWFGII TIALSSSLSP RLLGISLASL
     SSGMGELTFL QLTTTLPTEA TSKTALGAWS SGTGFAGVAG AGIWWLLRGL GVKGGLGLSS
     FLPLFFPITY KYILPPFSHL EASSDSSPYQ RLPMSSSLSN NNNFRPPAIL ISVPSSEYVP
     QHTPLLSSGF IDRDRDRNRD GEELTDGDKR LMGMRASRLT TQEKMKLLRP LVVRYMLPLC
     AVYVEEYVIN SGVAPTLVFP LPTYGLWSWL FKSPRDYYPF WSLTYQTFVF LSRSSLSLGL
     PPIPKRLLPL PAIIQFLVLS LLFLQAKTFF FSSPAYTPPA DGDGGVDRSI TIVFLLICLE
     GLCGGSGYVN TFYHVGREGS VSENYDADGD NEMGGDRRTV NVTEMEKKAM EREFRIGAVG
     AADSTGILFA SLISMPLEIA LCRSQVDQGR TMCREL