ID   BTN1_DEBHA              Reviewed;         414 AA.
AC   Q6BZ39;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Protein BTN1;
DE   Flags: Precursor;
GN   Name=BTN1; OrderedLocusNames=DEHA2A04796g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in vacuolar transport and vacuole pH homeostasis.
CC       Also required for cytokinesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
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DR   EMBL; CR382133; CAG84485.2; -; Genomic_DNA.
DR   RefSeq; XP_456530.2; XM_456530.1.
DR   AlphaFoldDB; Q6BZ39; -.
DR   STRING; 4959.XP_456530.2; -.
DR   PRIDE; Q6BZ39; -.
DR   EnsemblFungi; CAG84485; CAG84485; DEHA2A04796g.
DR   GeneID; 2899817; -.
DR   KEGG; dha:DEHA2A04796g; -.
DR   VEuPathDB; FungiDB:DEHA2A04796g; -.
DR   eggNOG; KOG3880; Eukaryota.
DR   HOGENOM; CLU_029663_1_2_1; -.
DR   InParanoid; Q6BZ39; -.
DR   OMA; WLCNWQV; -.
DR   OrthoDB; 1037817at2759; -.
DR   Proteomes; UP000000599; Chromosome A.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR003492; Battenin_disease_Cln3.
DR   InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10981; PTHR10981; 1.
DR   Pfam; PF02487; CLN3; 1.
DR   PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR   PRINTS; PR01315; BATTENIN.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..414
FT                   /note="Protein BTN1"
FT                   /id="PRO_0000256261"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          195..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  45507 MW;  C04FFB80313CCC78 CRC64;
     MQLLIPESRI VFASFFIFGL LNNILYVVIL SAAIDLVGSA TPKATVLLAD IIPSFTIKVM
     APFFVGLISY RTRIWMLVGL SSFGMLVISL TSDESINAKI VGICMASLSS GLGEVTFLQL
     THFYQREYSI SGFSSGTGGA GLLGSFVFML LTNMLGMKVW VVLLLFAVLP LGFLMAFYVM
     LPKARGGGGD EPGYEALDSL DERSDPSSNA SFSSSQTVSL KGHVVSTIKN ILPLIRPYML
     PLCLVYVSEY IINQGISPTL LFPLDELPHW LFSSYRDIYV VYGFMYQLGV FVSRSSISFG
     IRIKRLYLLS VLQFANVVIT VYQSVHDKPF SSVWLLLALI FYEGLLGGFS YVNTFMSVSE
     EVSKSKREFS MGCVGISDTF GILLAGCINW SLEPHLCSLQ VNRGRDWCLN GGSA