ID   BTN1_KLULA              Reviewed;         387 AA.
AC   Q6CLN9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Protein BTN1;
DE   Flags: Precursor;
GN   Name=BTN1; OrderedLocusNames=KLLA0F01551g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in vacuolar transport and vacuole pH homeostasis.
CC       Also required for cytokinesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG97857.1; -; Genomic_DNA.
DR   RefSeq; XP_455150.1; XM_455150.1.
DR   AlphaFoldDB; Q6CLN9; -.
DR   SMR; Q6CLN9; -.
DR   STRING; 28985.XP_455150.1; -.
DR   EnsemblFungi; CAG97857; CAG97857; KLLA0_F01551g.
DR   GeneID; 2895071; -.
DR   KEGG; kla:KLLA0_F01551g; -.
DR   eggNOG; KOG3880; Eukaryota.
DR   HOGENOM; CLU_029663_1_2_1; -.
DR   InParanoid; Q6CLN9; -.
DR   OMA; WLCNWQV; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0000324; C:fungal-type vacuole; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1903826; P:L-arginine transmembrane transport; IEA:EnsemblFungi.
DR   GO; GO:0015819; P:lysine transport; IEA:EnsemblFungi.
DR   GO; GO:0051453; P:regulation of intracellular pH; IEA:EnsemblFungi.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR003492; Battenin_disease_Cln3.
DR   InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10981; PTHR10981; 1.
DR   Pfam; PF02487; CLN3; 2.
DR   PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR   PRINTS; PR01315; BATTENIN.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..387
FT                   /note="Protein BTN1"
FT                   /id="PRO_0000256263"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   387 AA;  43485 MW;  A06C21B2D95932D3 CRC64;
     MELDRDKKTF AYFWLFGLIN NILYVVILSA ASDIIGPSLP KSIVLLFDIM PSFLIKLSAP
     FFVHSIHYDK RIPILILLSM LGIILVSTRS LWLCLPGIVL ASLSSGFGEI TFLQLTHFFG
     SKSLTGWSSG TGGAGIVGSF SYLLLTTVFR LNIQLSLLLY AALPLIFLLY YKINDSIVSS
     QVYQSLDMPI DSSDGPIELL KSNGWVDIVK RLSKLVIPYM IPLSTVYLFE YLINQGVAPT
     LLFPIDTTPF VKYRDIYVTY GTLYQLGVFI SRTWGHKLPV KNLYLFSVLQ LINLLITLSQ
     SYYYWTDSIS WIMVLIFYEG LIGGSSYVNC FMNILKDVDP NEREFVLGSV SISDSLGTLI
     AAFLGIILEP SLCKHQIGTG RPWCRME