ID   BTN1_YARLI              Reviewed;         395 AA.
AC   Q6BZW3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Protein BTN1;
DE   Flags: Precursor;
GN   Name=BTN1; OrderedLocusNames=YALI0F30415g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in vacuolar transport and vacuole pH homeostasis.
CC       Also required for cytokinesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the battenin family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78862.1; -; Genomic_DNA.
DR   RefSeq; XP_506049.1; XM_506049.1.
DR   AlphaFoldDB; Q6BZW3; -.
DR   SMR; Q6BZW3; -.
DR   STRING; 4952.CAG78862; -.
DR   EnsemblFungi; CAG78862; CAG78862; YALI0_F30415g.
DR   GeneID; 2907917; -.
DR   KEGG; yli:YALI0F30415g; -.
DR   VEuPathDB; FungiDB:YALI0_F30415g; -.
DR   HOGENOM; CLU_029663_1_2_1; -.
DR   InParanoid; Q6BZW3; -.
DR   OMA; WLCNWQV; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0000324; C:fungal-type vacuole; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1903826; P:L-arginine transmembrane transport; IEA:EnsemblFungi.
DR   GO; GO:0015819; P:lysine transport; IEA:EnsemblFungi.
DR   GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR003492; Battenin_disease_Cln3.
DR   InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10981; PTHR10981; 1.
DR   Pfam; PF02487; CLN3; 1.
DR   PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR   PRINTS; PR01315; BATTENIN.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..395
FT                   /note="Protein BTN1"
FT                   /id="PRO_0000256266"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   395 AA;  43400 MW;  104A194D9CFF21C9 CRC64;
     MQLEPAHLVY AAFWTFGLVN NVLYVVILTA AVDLVGPQTP KAVVLLADVL PSFLIKLAAP
     FFIHKIPYNR RITLLVGLST VGMMSVSLAS PLFLKLVGVV LASFSSGLGE VTFLQLTHFY
     DTRALNGWSS GTGGAGLVGS GLFMLLTTVL GVSVKTSLLV FAFFPLAFLG VYFYLLPPRD
     YNRVPGAFPV HSNDPETGIE TQPITWEFVA SGYETTMVRL KPLVMPYMLP LFLVYFSEYT
     INQGVAPTLL FPMEELPFSK FRDVYVTYGT LYQLGVFISR SSAPFVRIRR IMIPSVLQFA
     NLVFCIAQSM SPILPNVWLV FILIFYEGLL GGAAYVNTFL LITEQADLAE REFALGSVGM
     SDSAGIVLAG LVSLWLEPGL CNYQVNDGRG WCTLE