BTNL1_MOUSE
ID BTNL1_MOUSE Reviewed; 509 AA.
AC Q7TST0; A6X8K2; G3UZN0; O70356;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Butyrophilin-like protein 1;
DE Flags: Precursor;
GN Name=Btnl1; Synonyms=Btnl3, Gm316, Ng10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129;
RA Rowen L., Qin S., Loretz C., Mix L., Lasky S., Madan A., Hood L.;
RT "Sequence of the mouse major histocompatibility class II region.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-342.
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC05289.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAH52925.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH52925.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
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DR EMBL; AF050157; AAC05289.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CR974457; CAO77747.1; -; Genomic_DNA.
DR EMBL; BC052925; AAH52925.1; ALT_SEQ; mRNA.
DR CCDS; CCDS50075.1; -.
DR RefSeq; NP_001104564.1; NM_001111094.1.
DR AlphaFoldDB; Q7TST0; -.
DR SMR; Q7TST0; -.
DR STRING; 10090.ENSMUSP00000079140; -.
DR iPTMnet; Q7TST0; -.
DR PhosphoSitePlus; Q7TST0; -.
DR MaxQB; Q7TST0; -.
DR PaxDb; Q7TST0; -.
DR PeptideAtlas; Q7TST0; -.
DR PRIDE; Q7TST0; -.
DR ProteomicsDB; 273715; -.
DR DNASU; 100038862; -.
DR Ensembl; ENSMUST00000080254; ENSMUSP00000079140; ENSMUSG00000062638.
DR GeneID; 100038862; -.
DR KEGG; mmu:100038862; -.
DR UCSC; uc012apy.1; mouse.
DR CTD; 100038862; -.
DR MGI; MGI:1932027; Btnl1.
DR VEuPathDB; HostDB:ENSMUSG00000062638; -.
DR eggNOG; ENOG502QSRZ; Eukaryota.
DR GeneTree; ENSGT00940000162079; -.
DR HOGENOM; CLU_013137_22_2_1; -.
DR InParanoid; Q7TST0; -.
DR OMA; ISYTGWR; -.
DR OrthoDB; 522383at2759; -.
DR PhylomeDB; Q7TST0; -.
DR TreeFam; TF331083; -.
DR BioGRID-ORCS; 100038862; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q7TST0; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q7TST0; protein.
DR Bgee; ENSMUSG00000062638; Expressed in jejunum and 12 other tissues.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0045062; P:extrathymic T cell selection; IMP:MGI.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..509
FT /note="Butyrophilin-like protein 1"
FT /id="PRO_0000014536"
FT TOPO_DOM 28..250
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..509
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 28..139
FT /note="Ig-like V-type 1"
FT DOMAIN 151..237
FT /note="Ig-like V-type 2"
FT DOMAIN 316..509
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT REGION 349..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 53..127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 167..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 22
FT /note="F -> S (in Ref. 3; AAH52925)"
FT /evidence="ECO:0000305"
FT CONFLICT 107
FT /note="M -> T (in Ref. 3; AAH52925)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="M -> T (in Ref. 3; AAH52925)"
FT /evidence="ECO:0000305"
FT CONFLICT 328
FT /note="L -> S (in Ref. 3; AAH52925)"
FT /evidence="ECO:0000305"
FT CONFLICT 332..337
FT /note="DWRKEL -> AIDLSN (in Ref. 3; AAH52925)"
FT /evidence="ECO:0000305"
FT CONFLICT 339..341
FT /note="QEA -> CIK (in Ref. 3; AAH52925)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 509 AA; 57726 MW; 8302DFBA7C3C8826 CRC64;
MMKGSPSVPP AGCLLPLLLL LFTGVSGEVS WFSVKGPAEP ITVLLGTEAT LPCQLSPEQS
AARMHIRWYR AQPTPAVLVF HNGQEQGEVQ MPEYRGRTQM VRQAIDMGSV ALQIQQVQAS
DDGLYHCQFT DGFTSQEVSM ELRVIGLGSA PLVHMTGPEN DGIRVLCSSS GWFPKPKVQW
RDTSGNMLLS SSELQTQDRE GLFQVEVSLL VTDRAIGNVI CSIQNPMYDQ EKSKAILLPE
PFFPKTCPWK VALVCSVLIL LVLLGGISLG IWKEHQVKRR EIKKWSKEHE EMLLLKKGTK
SVLKIRDDLQ ADLDRRKALY KEDWKKALLY PDWRKELFQE APVRINYEMP DQDKTDSRTE
ENRGEETVSS SQVDHNLITL SQEGFMLGRY YWEVDVKDTE EWTLGVYELC TQDASLTDPL
RKFRVLEKNG DGYRALDFCS QNINSEEPLQ LKTRPLKIAI FLDQEDNDLS FYNMTDETHI
FSFAQVPFLG SPYPYFTRNS MGLSATAQP
