ID   TOLB_VIBC3              Reviewed;         450 AA.
AC   A5F753; C3M1M9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Tol-Pal system protein TolB {ECO:0000255|HAMAP-Rule:MF_00671};
DE   Flags: Precursor;
GN   Name=tolB {ECO:0000255|HAMAP-Rule:MF_00671};
GN   OrderedLocusNames=VC0395_A1429, VC395_1951;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10692381; DOI=10.1128/jb.182.6.1739-1747.2000;
RA   Heilpern A.J., Waldor M.K.;
RT   "CTXphi infection of Vibrio cholerae requires the tolQRA gene products.";
RL   J. Bacteriol. 182:1739-1747(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Part of the Tol-Pal system, which plays a role in outer
CC       membrane invagination during cell division and is important for
CC       maintaining outer membrane integrity. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
CC   -!- SUBUNIT: The Tol-Pal system is composed of five core proteins: the
CC       inner membrane proteins TolA, TolQ and TolR, the periplasmic protein
CC       TolB and the outer membrane protein Pal. They form a network linking
CC       the inner and outer membranes and the peptidoglycan layer.
CC       {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00671}.
CC   -!- SIMILARITY: Belongs to the TolB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00671}.
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DR   EMBL; AF187269; AAG17042.1; -; Genomic_DNA.
DR   EMBL; CP000627; ABQ20859.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP09945.1; -; Genomic_DNA.
DR   RefSeq; WP_000476637.1; NZ_JAACZH010000001.1.
DR   AlphaFoldDB; A5F753; -.
DR   SMR; A5F753; -.
DR   STRING; 345073.VC395_1951; -.
DR   EnsemblBacteria; ABQ20859; ABQ20859; VC0395_A1429.
DR   GeneID; 57740471; -.
DR   KEGG; vco:VC0395_A1429; -.
DR   KEGG; vcr:VC395_1951; -.
DR   PATRIC; fig|345073.21.peg.1885; -.
DR   eggNOG; COG0823; Bacteria.
DR   HOGENOM; CLU_047123_0_0_6; -.
DR   OMA; VREPSWG; -.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0017038; P:protein import; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 1.
DR   HAMAP; MF_00671; TolB; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR014167; Tol-Pal_TolB.
DR   InterPro; IPR007195; TolB_N.
DR   Pfam; PF07676; PD40; 3.
DR   Pfam; PF04052; TolB_N; 1.
DR   TIGRFAMs; TIGR02800; propeller_TolB; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Periplasm; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT   CHAIN           23..450
FT                   /note="Tol-Pal system protein TolB"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00671"
FT                   /id="PRO_1000072720"
SQ   SEQUENCE   450 AA;  49645 MW;  360F2A88E9663505 CRC64;
     MFKRLVFVLM LIGTGFSNIA NAALELVITD GIDSARPIAI VPFKWEGATK LPEDVSAVIA
     SDLQRSGKFS PVPTSKMPQT PYSEEQVNFG KWTSMGVDSL LTGTITQNAE GSYVISYQLV
     DIVRGQLTQG QSKALSQDGQ LVLSKDHVLF NKVATVPASR MREYAHRIAD LVYEELTGER
     GAFLTRIAYV VVNDKDPYPY QLRIADYDGY NERLVLRSKQ PLMSPAWSPD GQTLAYVSFQ
     NGQAEIYMMN IYSGKREKLT SFPRHNGAPR FSPDGKTLAL VLSKTGNLQV YTMDLATRRL
     TEVTSGRSNN TEPFWHPDGK SLIFTSDRGG KPQIYQVNLS GGETKRLTWQ GSQNLGGQIT
     PDGKFLVMVN RSDSGFNLAK QDLETGAMQI LTKTLLDESP SIAPNGGMVI YSSIYNKANV
     LSMVSIDGRF KARLPATNGR VRAPAWSPFL